Prostate Cancer Foundation 2018 Scientific Retreat

Prostate Cancer Foundation 2018 Scientific Retreat

INTERVIEW WITH ANDREA MIYAHIRA
The Prostate Cancer Foundation: A Discussion with Andrea Miyahira

VIEW ALL PCF VIDEOS

Prostate Cancer Foundation 2018 Scientific Retreat

Prostate Cancer Foundation 2018 Scientific Retreat

INTERVIEW WITH KENNETH PIENTA
The Process of Metastasis in Prostate Cancer

VIEW ALL PCF VIDEOS

European Society for Medical Oncology 2018 Congress

European Society for Medical Oncology 2018 Congress

INTERVIEW WITH FRED SAAD
A Renewed Analysis of ERA 223

VIEW ALL ESMO VIDEOS

Videos
State-of-the-industry video lectures by leading urology experts
Latest Videos
Featured Videos

ORLANDO, FL USA (UroToday.com) - Prostate cancer biomarkers have tremendous potential to influence decisions regarding treatment and active surveillance. The CCP (cell cycle progression) score is a 46-gene expression level biomarker already known to be a robust predictor of prostate cancer outcomes. Dr. Jack Cuzick and colleagues performed validation of the CCP score and a combined clinical risk score (CCR + clinical variables) for predicting disease-specific mortality (DSM) in a cohort of conservatively managed patients diagnosed by needle biopsy. CCP score was calculated by extracting mRNA from prostate needle biopsy specimens in 757 men diagnosed with clinically localized prostate cancer. The primary endpoint was disease specific mortality, with a mean clinical follow-up of 10.6 years.

auaA change in the CCP score from the 25th to 75th percentile increased the hazard of DSM by 2.3 fold. Following multivariable analysis, CCP remained associated with an increased risk of DSM (HR 1.86). Of the variables examined, including CAPRA score and clinical parameters, CCP was the most significant independent prognostic factor for DSM. The CCR score was also predictive of DSM, while addition of CAPRA did not add significant prognostic information to the CCR score. CCP provides significant pre-treatment prognostic information for patients managed conservatively with active surveillance or watchful waiting, and is a valuable addition for the informed management of newly diagnosed PC patients.

Presented by Peter T. Scardino, MD, FACS at the American Urological Association (AUA) Annual Meeting - May 16 - 21, 2014 - Orlando, Florida USA

Click HERE to listen to Peter Scardino, MD, FACS discuss the study.

Click HERE to view the poster from this session.

Memorial Sloan Kettering Cancer Center, New York, NY USA

Written by Jeffrey J. Tomaszewski, MD, medical writer for UroToday.com.

 

Clinical Trials
Searchable data base of currently enrolling clinical trials
Journals
Publications focusing on urological cancer treatments through original commentary & articles
Everyday Urology Volume 3 Issue 3

Everyday Urology™ - Oncology Insights

PCAN cover

Prostate Cancer and Prostatic Diseases

From the Editor

@UroToday
E-Newsletters

Newsletter subscription

Free Daily and Weekly newsletters offered by content of interest

The fields of GU Oncology and Urology are rapidly advancing. Sign up today for articles, videos, conference highlights and abstracts from peer-review publications by disease and condition delivered to your inbox and read on the go.

Subscribe

Calendar
Upcoming educational events
December 13-16, 2018 / ESMO Immuno-Oncology Congress 2018
ESMO Immuno-Oncology Congress 2018
January 17-19, 2019 /
SNMMI 2019 Mid-Winter Meeting