Video Lectures
State-of-the-industry video lectures by leading urology experts
Latest Videos

ORLANDO, FL USA ( - In patients with high-risk prostate cancer (PC), radiation therapy (RT) is frequently offered following prostatectomy, but response rates vary. The authors assessed the ability of the genomic classifier (GC) (DecipherTM) to predict clinical progression in men following post-RP RT. Approximately 200 patients from a multi-institutional cohort (Thomas Jefferson University and Mayo clinic), treated with post-RP RT, were evaluated to assess the ability of GC scores to predict BCR, clinical metastasis, and distant metastasis. Among the Mayo cohort, the AUC for GC was 0.78 for clinical metastasis. Among the Jefferson cohort, use of GC score improved AUC to 0.75 and 0.77 for BCR and distant metastasis, respectively.

auaIn both cohorts, GC was the most significant predictor of clinical progression after RT. Following multivariable adjustment for GC, CAPRA-S, and concurrent hormone therapy, patients with high GC had a 7-fold increased risk of BCR. A similar trend for clinical metastasis was observed in the Mayo cohort, but statistical significance was not reached. Incorporation of GC score in patient post-RP RT predicted treatment failure and improved risk stratification. Increased GC score following post-RP RT was significantly associated with higher risk for clinical progression. The use of GC score to influence and sequence systemic therapy requires further investigation.

Presented by Edouard J. Trabulsi, MD at the American Urological Association (AUA) Annual Meeting - May 16 - 21, 2014 - Orlando, Florida USA

Thomas Jefferson University Hospitals, Philadelphia, PA USA

Written by Jeffrey J. Tomaszewski, MD, medical writer for

AUA 2014, #AUA14, radiation therapy (RT), genomic classifier (GC)


Editor selected abstracts and commentaries
Clinical Trials
Searchable data base of currently enrolling clinical trials
Upcoming urology industry events
February 24, 2018 / Charleston Marriott
Advances in Cancer Immunotherapy™ - Charleston, SC
February 24, 2018 /
2018 IUA Annual Meeting
February 26-27, 2018 / The Royal Marsden Hospital
MediSens – The European Medical Imaging Conference
February 27-March 3, 2018 /
SUFU 2018 Winter Meeting
March 1-3, 2018 / Omni Amelia Island Plantation Resort, Fernandina Beach, FL
75th Annual Meeting Mid-Atlantic Section of the American Urological Association
Print publications focusing on urological cancer treatments through original commentary & articles

Everyday Urology™ - Oncology Insights

From the Editor

Prostate Cancer and Prostatic Diseases

From the Editor