Video Lectures
State-of-the-industry video lectures by leading urology experts
Latest Videos

ORLANDO, FL USA (UroToday.com) - During the “Advanced Prostate Cancer II” session, Dr. Neal Shore presented further data from the ALSYMPCA trial. ALSYMPCA is a Phase 3 trial of Ra-223 for the treatment of symptomatic metastatic castrate-resistant prostate cancer (mCRPC) in patients with no known visceral mets. Ra-223, an alpha-emitting pharmaceutical, has been shown to significantly prolong overall survival and time to first symptomatic skeletal event, compared to placebo. Of the 921 patients randomized, 57% and 43% had prior or no prior docetaxel (D+/D-), respectively, and safety data from the predefined ALSYMPCA D subgroups were presented.

auaRegardless of D use, Ra-223 significantly prolonged overall survival (D+, HR = 0.70; D-, HR = 0.69). The risk of skeletal events was also reduced in the D+ and D- groups. D- patients did have lower rates of grade 3 or 4 anemia, neutropenia, and thrombocytopenia compared to the D+ group, but the overall frequency of grade 3 or 4 adverse events was low. A subgroup of 147 patients receiving chemotherapy after Ra-223 demonstrated comparable rates of grade 3 or 4 anemia and neutropenia between D+ and D- groups.

Dr. Shore concluded that Ra-223 significantly prolongs OS with a favorable safety profile in mCRPC patients with symptomatic bone metastases regardless of D use. Rates of grade 3 or 4 hematologic adverse events were slightly higher in D+ patients.

Click HERE to view the poster from this session

Presented by Neal D. Shore, MD, FACS at the American Urological Association (AUA) Annual Meeting - May 16 - 21, 2014 - Orlando, Florida USA

Myrtle Beach, SC USA

Written by Jeffrey J. Tomaszewski, MD, medical writer for UroToday.com

 

 

Clinical Trials
Searchable data base of currently enrolling clinical trials
Calendar
Upcoming urology industry events
February 26-27, 2018 / The Royal Marsden Hospital
MediSens – The European Medical Imaging Conference
February 27-March 3, 2018 /
SUFU 2018 Winter Meeting
March 1-3, 2018 / Omni Amelia Island Plantation Resort, Fernandina Beach, FL
75th Annual Meeting Mid-Atlantic Section of the American Urological Association
March 1-3, 2018 / Marriott St. Louis Airport, St. Louis, Missouri
2018 Bladder Cancer Academy
March 3, 2018 / DoubleTree by Hilton Hotel Dallas - Campbell Centre
Advances in Cancer Immunotherapy™ - Dallas, TX
Journals
Print publications focusing on urological cancer treatments through original commentary & articles

Everyday Urology™ - Oncology Insights

From the Editor

Prostate Cancer and Prostatic Diseases

From the Editor

@UroToday