STOCKHOLM, SWEDEN (UroToday.com) - In this trial, 918 men (median PSA of 15.9ng/ml) were randomized with inclusion criteria being: histologically confirmed prostate adenocarcinoma, cT3–cT4 M0 or M1, serum PSA > 4 ng/ml and PSA ≤ 100 ng/ml age ≤ 80 years, World Health Organization (WHO) performance status 0–2, and normal liver function not suitable for definitive treatment. On registration, they were able to collect data on statin use from 252 patients, of whom 129 did not use statins and 123 used statins. Among this subgroup of patients, 115 received continuous therapy and 137 intermittent therapy. Within the continuous arm, 49.6% of patients used statins, while among the intermittent arm, 48.2% used statins. eauAmong those who used statins, 21 died (12 from prostate cancer, 5 from CVD, 4 from other causes) and among those who did not use statins 45 died (25 from prostate cancer, 14 from CVD, 6 from other causes). They reported that for prostate cancer death, the corresponding hazard ratio was 0.44 (95% CI 0.22-0.90, p = 0.025), and for CVD death it was 0.30 (95% CI 0.11, 0.83, p = 0.020). The only factors that were associated with overall survival were metastatic status and statins use, HR=0.39 (95% CI 0.23-0.65, p = 0.0004).

In 2013, Geybels, et al. reported that prior use of statins is associated with better survival among men with newly diagnosed prostate cancer. In this retrospective sub-analysis of a phase 3 randomized clinical trial, authors were also able to show the protective effect of statin use on prostate cancer mortality. Further studies, using larger cohorts, are needed to further evaluate the effect of this medication on prostate cancer mortality.

Presented by F. Calais Da Silva, Jr.,1 F. Calais Da Silva, Sr.,1 F. Gonçalves,2 J. Kliment,3 P. Whelan,4 N. Antoniou,5 S. Pastidis,6 Y. Beduk,7 and C. Robertson8 at the 29th Annual European Association of Urology (EAU) Congress - April 11 - 15, 2014 - Stockholmsmässan - Stockholm, Sweden.

1Hospital de São José, Dept. of Urology, Lisbon, Portugal, 2Klinika LFUK School of Medicine, Dept. of Urology, Bratislava, Slovakia, 3Jessenius School of Medecine, Dept. of Urology, Martin, Slovakia, 4St.James Univ. Hosp., Dept. of Urology, Leeds, United Kingdom, 5Amalia Fleming Hospital-, Dept. of Urology, Athens, Greece, 6Amalia Fleming Hospital, Dept. of Urology, Athens, Greece, 7Ankara Univ. Medical Ibni Siha, Dept. of Urology, Ankara, Turkey, 8Univ. of Strathclyde -, Dept. of Statistics, Glasgow, United Kingdom

Written by Reza Mehrazin, MD, medical writer for UroToday.com

 

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