Featured Videos

ORLANDO, FL USA (UroToday.com) - Histotripsy is a non-thermal pulsed high-intensity focused ultrasound technology that homogenizes a target tissue. George R. Schade and colleagues developed a new technique termed boiling histotripsy. Because it is a non-invasive approach, it offers several advantages over conventional techniques. The researchers’ aim was to evaluate their technique in fresh porcine and human kidney to demonstrate feasibility of the technique.

auaThe researchers used 20 porcine kidneys and 6 fresh human renal tissues. Tissue was degassed for greater than 30 minutes in buffered saline and then treated with boiling histotripsy. Treated tissue was then evaluated both grossly and using histology.

The authors found that the medulla was more resistant to their boiling histotripsy technique than cortical tissue. Histologically, lesions were found to be comet shaped. The collecting system was still more resistant, where the authors found that more than 120 pulses were required.

The authors concluded that boiling histotripsy is feasible. The finding that collecting systems are resistant to this technique can produce numerous benefits in terms of correct management of renal masses. Their similarity of findings in both human and porcine models is important in that it paves the way for more studies to be performed on this topic. It would be beneficial to also study the mechanisms that are responsible for the results the authors observed.

Presented by George R. Schade, MD at the American Urological Association (AUA) Annual Meeting - May 16 - 21, 2014 - Orlando, Florida USA

University of Washington, Seattle, WA USA

Written by Garen Abedi, MD, University of California (Irvine), and medical writer for UroToday.com

 

Clinical Trials
Searchable data base of currently enrolling clinical trials
Journals
Publications focusing on urological cancer treatments through original commentary & articles
Everyday Urology Volume 3 Issue 2

Everyday Urology™ - Oncology Insights

From the Editor

PCAN cover

Prostate Cancer and Prostatic Diseases

From the Editor

@UroToday
E-Newsletters

Newsletter subscription

Free Daily and Weekly newsletters offered by content of interest

The fields of GU Oncology and Urology are rapidly advancing. Sign up today for articles, videos, conference highlights and abstracts from peer-review publications by disease and condition delivered to your inbox and read on the go.

Subscribe

Calendar
Upcoming educational events
November 23-25, 2018 / European Society for Medical Oncology Asia 2018 Congress
European Society for Medical Oncology Asia 2018 Congress
November 25-30, 2018 / RSNA 2018 Annual Meeting
RSNA 2018 Annual Meeting