SAN FRANCISCO, CA USA (UroToday.com) - Dr. Stephanie Anne Holler Howard from department of radiology at Dana-Faber Cancer Institute presented an abstract on whether or not retroperitoneal craniocaudal nodal length (CCNL) or nodal volume (NV) can predict relapse risk in clinical stage I testicular cancer.

This was a retrospective study of 118 patients with stage I testicular cancer with either more than or equal to 2-years surveillance, or retroperitoneal lymph node dissection with no adjuvant chemotherapy.

gucancerssympalt thumb thumbFifty-six percent had nonseminomatous germ-cell tumor (NSGCT) and 44% had seminomatous germ-cell tumor (SGCT). Twenty-one percent (25 out of 118) of patients relapsed: 24% (16 out of 66) for NSGCT and 17% (9 out of 52) for SGCT. 90% of these were at the site of the largest lymph node. On a multivariable logistic regression model adjusting for other potential known risk factors of embryonal predominance (EP) and lymphovascular invasion (LVI), CCNL proved to be an independent risk factor in NSGCT For every 3 mm increase in CCNL; the risk of relapse increased by 52% (odds ratio [OR]=1.52; 95% CI=1.03- 2.25). For patients with SGCT, only the primary tumor size was an independent risk factor for relapse (OR=1.34; 95% CI=1.02-1.75). For patients who had CCNL size > 1.5 cm, they were 4 times more likely to have relapse of disease. Although their findings are valuable, external validation using larger cohorts is needed to further validate if CCNL could provide additional information in management of these patients.

Highlights of a presentation by Stephanie Anne Holler Howard, MD at the 2014 Genitourinary Cancers Symposium - January 30 - February 1, 2014 - San Francisco Marriott Marquis - San Francisco, California USA

Dana-Faber Cancer Institute, Boston, MA USA

Written by Reza Mehrazin, MD, medical writer for UroToday.com


View Full 2014 GU Cancers Symposium Coverage

 

 

Calendar
Upcoming urology industry events
April 27-29, 2018 / European Society for Medical Oncology Update for Practising Oncologists
European Society for Medical Oncology Update for Practising Oncologists
May 14, 2018 / InterContinental Mark Hopkins Hotel
SITC Cancer Immune Responsiveness Workshop
May 16-17, 2018 / InterContinental Mark Hopkins Hotel
SITC Immuno-Oncology Biomarkers: State of the Art Workshop
May 17, 2018 / Moscone Convention Center North/South, San Francisco, CA
SAU 2018 Annual Meeting at the AUA
Journals
Print publications focusing on urological cancer treatments through original commentary & articles

Everyday Urology™ - Oncology Insights

From the Editor

Prostate Cancer and Prostatic Diseases

From the Editor