Featured Videos

SAN FRANCISCO, CA USA (UroToday.com) - In this session Dr. Eliezer M. Van Allen discussed the potential role for next generation sequencing (NGS) technologies in developing an individualized approach to the treatment of bladder cancer.

Dr. Van Allen started with a summary of the NGS technologies. NGS profiling identifies all mutations present within the genetic material that is tested, which can range in scope from a predefined set of exons (targeted sequencing) to the entire exome or whole genome sequencing. Targeted and exome sequencing are now ready for use in the clinical setting.

gucancerssympalt thumbCurrently therapeutic decision making is fairly limited in bladder cancer. The goal of the insertion of NGS profiling in this decision-making process, Dr. Van Allen elaborated, was to identify mutations specific to an individual patient’s cancer which could lead to the use of novel targeted therapeutics. NGS profiling could also help to identify patients more or less likely to respond to standard therapies.

Recent studies have demonstrated multiple potential targets in bladder cancer, including FGFR, RAF, MET, mTOR, PI3K and AKT1. Dr. Van Allen discussed his work with NGS profiling of over 500 exomes in diverse bladder tumor types and reported the presence of a “long tail” of mutated clinically relevant cancer genes – namely a large number of genes mutated at a low frequency. This fact emphasizes the need for individualized treatment strategies given the significant heterogeneity present within bladder cancer. Dr. Van Allen further explained that through the use of an algorithm developed in his lab called “PHIAL”, clinical and biologic relevance of any identified pathway alterations could be ranked, and thus targeted therapies most likely to be efficacious could be identified.

Dr. Van Allen finally discussed potential future applications of NGS in bladder cancer. The identification of mutations related to the development of clinical resistance through profiling of tumor tissue, before and after development of resistance, could help to drive the identification of new therapeutic targets. Ultimately the hope would be that NGS profiling would continue to identify new targets within an individual patient’s cancer that would allow for utilization of new targeted therapies that could potentially keep a patient’s cancer at bay indefinitely.

Highlights of a presentation by Eliezer M. Van Allen, MD at the 2014 Genitourinary Cancers Symposium - January 30 - February 1, 2014 - San Francisco Marriott Marquis - San Francisco, California USA

Dana-Farber Cancer Institute, Boston, MA USA

Written by Timothy Ito, MD, medical writer for UroToday.com


View Full 2014 GU Cancers Symposium Coverage

 

 

Clinical Trials
Searchable data base of currently enrolling clinical trials
Journals
Publications focusing on urological cancer treatments through original commentary & articles
Everyday Urology Volume 3 Issue 2

Everyday Urology™ - Oncology Insights

From the Editor

PCAN cover

Prostate Cancer and Prostatic Diseases

From the Editor

@UroToday
E-Newsletters

Newsletter subscription

Free Daily and Weekly newsletters offered by content of interest

The fields of GU Oncology and Urology are rapidly advancing. Sign up today for articles, videos, conference highlights and abstracts from peer-review publications by disease and condition delivered to your inbox and read on the go.

Subscribe

Calendar
Upcoming educational events
November 23-25, 2018 / European Society for Medical Oncology Asia 2018 Congress
European Society for Medical Oncology Asia 2018 Congress
November 25-30, 2018 / RSNA 2018 Annual Meeting
RSNA 2018 Annual Meeting