The glutathione-S-transferases (GSTs) comprise a class of enzymes that detoxify carcinogenic compounds by conjugating glutathione to facilitate their removal.
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Investigational Urology
| Association of genetic polymorphism of glutathione S-transferase (GSTM1, GSTT1, GSTP1) with bladder cancer susceptibility - Abstract |
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Thu, 23 February 2012
Last Updated ( Thu, 09 February 2012 )
Login to read more...| Stress-activated kinase pathway alteration is a frequent event in bladder cancer - Abstract |
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Thu, 23 February 2012
OBJECTIVES: The stress-activated MAP kinases (SAPK) signaling pathways play a critical role in the cellular response to toxins and physical stress, mediate inflammation, and modulate carcinogenesis and tumor metastasis.
Last Updated ( Thu, 09 February 2012 )
Login to read more...| Tissue-specific mutagenesis by N-butyl-N-(4-hydroxybutyl)nitrosamine as the basis for urothelial carcinogenesis - Abstract |
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Thu, 23 February 2012
Bladder cancer is one of the few cancers that have been linked to carcinogens in the environment and tobacco smoke.
Last Updated ( Thu, 09 February 2012 )
Login to read more...| Differential expression of the androgen-conjugating UGT2B15 and UGT2B17 enzymes in prostate tumor cells during cancer progression - Abstract |
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Thu, 23 February 2012
Context: Androgens play major roles in prostate cancer initiation and development.
Last Updated ( Thu, 09 February 2012 )
Login to read more...| Upregulation of mTORC2 activation by the selective agonist of EPAC, 8-CPT-2Me-cAMP, in prostate cancer cells: Assembly of a multi-protein signaling complex - Abstract |
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Wed, 22 February 2012
Ligation of cell surface-associated GRP78 by activated α(2) -macroglobulin triggers pro-proliferative cellular responses.
Last Updated ( Thu, 09 February 2012 )
Login to read more...| Effect of transforming growth factor beta (TGF-β) receptor I kinase inhibitor on prostate cancer bone growth - Abstract |
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Wed, 22 February 2012
Transforming growth factor beta 1 (TGF-β1) has been implicated in the pathogenesis of prostate cancer (PCa) bone metastasis.
Last Updated ( Thu, 09 February 2012 )
Login to read more...| SOD mimetics: A novel class of androgen receptor inhibitors that suppresses castration-resistant growth of prostate cancer - Abstract |
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Wed, 22 February 2012
Advanced prostate cancer is the second leading cause of cancer-related deaths among American men.
Last Updated ( Thu, 09 February 2012 )
Login to read more...| Bee venom induces apoptosis through intracellular Ca2+ -modulated intrinsic death pathway in human bladder cancer cells - Abstract |
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Wed, 22 February 2012
OBJECTIVES: To focus on bee venom-induced apoptosis in human bladder cancer TSGH-8301 cells and to investigate its signaling pathway to ascertain whether intracellular calcium iron (Ca(2+)) is involved in this effect.
Last Updated ( Thu, 09 February 2012 )
Login to read more...| Beyond the Abstract - Investigative models in erectile dysfunction: A state-of-the-art review of current animal models, by Eric Chung, FRACS |
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Tue, 14 February 2012
BERKELEY, CA (UroToday.com) - Over the last few decades, there have been considerable advances made in our understanding of the pathophysiology and molecular basis of erectile dysfunction (ED).
Last Updated ( Tue, 14 February 2012 )
Login to read more...| A systematic analysis on DNA methylation and the expression of both mRNA and microRNA in bladder cancer - Abstract |
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Mon, 13 February 2012
BACKGROUND: DNA methylation aberration and microRNA (miRNA) deregulation have been observed in many types of cancers.
Last Updated ( Tue, 07 February 2012 )
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