UroToday - UroToday :: 24-h Uric Acid Excretion and the Risk of Kidney Stones

24-h Uric Acid Excretion and the Risk of Kidney Stones - abstract

Monday, 04 February 2008

Department of Medicine, Renal Division, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA; Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA.

There is uncertainty about the relation between 24-h urinary uric acid excretion and the risk of calcium oxalate nephrolithiasis. In addition, the risk associated with different levels of other urinary factors needs clarification. We performed a cross-sectional study of 24-h urine excretion and the risk of kidney stone formation in 3350 men and women, of whom 2237 had a history of nephrolithiasis. After adjusting for other urinary factors, urinary uric acid had a significant inverse association with stone formation in men, a marginal inverse association with risk in younger women, and no association in older women. The risk of stone formation in men and women significantly rose with increasing urine calcium and oxalate, and significantly decreased with increasing citrate and urine volume, with the change in risk beginning below the traditional normal thresholds. Other urinary factors were also associated with risk, but this varied by age and gender. Our study does not support the prevailing belief that higher urine uric acid excretion increases the risk for calcium oxalate stone formation. In addition, the current definitions of normal levels for urinary factors need to be re-evaluated.

Written by
Curhan GC, Taylor EN.

Reference
Kidney International (2008) 73, 489–496.
doi:10.1038/sj.ki.5002708

PubMed Abstract
PMID:18059457

UroToday.com Urolithiasis Section

Reader Comments

MD
Written by This email address is being protected from spam bots, you need Javascript enabled to view it on 2008-02-20 04:02:44

This paper is very interesting, I work in a hospital, which is in Guangzhou,south China. We have a lot of urinary stone patient. I also want to do some research work about the formation of stone. I want to know if there are some hospitals in America provide free trainning for this kind of work or something like this. By the way how can I get the above full paper. I really apppreciate it. Thank you.
With my best

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