Signaling through estrogen receptors modulates long non-coding RNAs in prostate cancer.

Prostate cancer (PCa) is a sex-steroid hormone-dependent cancer in which estrogens play a critical role in both initiation and progression. Recently, several long non-coding RNAs (lncRNAs) have been associated with PCa and are supposedly playing a pivotal role in the biology and progression of this type of cancer. In this review, we focused on some lncRNAs that are known for their androgen and estrogen transcriptional responsiveness in PCa. Specifically, we summarized recent pieces of evidence about lncRNAs NEAT1, H19, MALAT1, and HOTAIR, in estrogen signaling, emphasizing their role in PCa progression and the acquisition of a castration-resistant phenotype. Here, the reader will find information about lncRNAs present in estrogen-dependent transcriptional complexes. The potential role of lncRNA/estrogen signaling as a novel pathway for PCa treatment will be discussed.

Molecular and cellular endocrinology. 2020 May 12 [Epub ahead of print]

Simona Nanni, Lorenza Bacci, Aurora Aiello, Agnese Re, Chiara Salis, Claudio Grassi, Alfredo Pontecorvi, Carlo Gaetano, Antonella Farsetti

Dipartimento di Chirurgia e Medicina Traslazionale, Università Cattolica del Sacro Cuore, 00168, Roma, Italy; Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italy. Electronic address: ., Dipartimento di Chirurgia e Medicina Traslazionale, Università Cattolica del Sacro Cuore, 00168, Roma, Italy., Institute for Systems Analysis and Computer Science "A. Ruberti" (IASI), National Research Council (CNR), 00185, Rome, Italy., Dipartimento di Neuroscienze, Università Cattolica del Sacro Cuore, 00168, Roma, Italy; Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italy., Dipartimento di Chirurgia e Medicina Traslazionale, Università Cattolica del Sacro Cuore, 00168, Roma, Italy; Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italy., Laboratorio di Epigenetica, Istituti Clinici Scientifici Maugeri IRCCS, 27100, Pavia, Italy. Electronic address: ., Institute for Systems Analysis and Computer Science "A. Ruberti" (IASI), National Research Council (CNR), 00185, Rome, Italy. Electronic address: .