This course aims to provide a complete overview of the pathogenesis and evidence-based medical management of chronic kidney disease (CKD). The course will concentrate on all aspects of CKD from diagnosis and referral through to end-stage renal failure. Participants will gain an understanding of the underlying physiology and scientific background of the development and progression of CKD. These aspects will be integrated with the clinical management of people with increasing renal impairment until they reach end-stage renal failure and require renal replacement therapy. In addition, community issues and social, psychological, ethical and economic implications of CKD for patients will be examined. Current guidelines for the management of CKD, including the National Service Framework, the Renal Registry and, in particular, estimated GFR (eGFR) and its interpretation will be discussed.