• The peak of onset is ages 20-40 with another rise after age 60. The incidence is variable among different ethnic groups, but African Americans have approximately one third the incidence of Caucasian populations. Patterns of genetic inheritance have emerged yet account for a small overall percentage of these lesions.
• Seminomas account for 30-60 of these lesions and mixed germ cell tumors represent up to 60 percent of lesions. Pure choriocarcinoma occurs in one percent of lesions, while pure embrynonal [3-4%] and pure teratoma [5-10%] make up slightly higher proportions of reported series

References

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• Donohue JP, Thornhill JA, Foster RS, Bihrle R, Rowland RG, Einhorn LH: The role of retroperitoneal lymphadenectomy in clinical stage B testis cancer: The Indiana University experience (1965 to 1989). J Urol 153:85-89, 1995.
• Einhorn LH: Salvage therapy for germ cell tumors. Semin Oncol 21:47-51, 1994.
• Einhorn LH, Donohue JP: Advanced testicular cancer: Update for urologists. J Urol 160:1964-1969. 1998.
• Moller H, Skakkeback NE: Testicular cancer and cryptorchidism in relation to prenatal factors: Case control studies in Denmark. Cancer Causes Control 8:904-12, 1997.
• Nichols C, Loehrer P Sr: The story of second cancers in patients cured of testicular cancer: Tarnishing success of burnishing irrelevance. J Natl Cancer Inst 89:1304-1305, 1997.
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