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Overactive Bladder (OAB)

Overactive Bladder

UroToday's Overactive Bladder section is a repository of the clinical publications, clinical trials and investigative science pertaining to the diagnosis and treatment of overactive bladder. Also available are conference coverage for all timely overactive bladder science, audio podcasts and downloadable slides from UroToday's slide library.

Online Urology & Urologic Oncology Journal
Please read about the UroToday International Journal; We welcome submissions year round and are committed to providing fast-tracked, peer reviewed publication.
Kind regards,
Christian Gratzke, MD
Associate Section Editor Overactive Bladder
UroToday International Journal

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AUA NY 2009 - Primary bladder neck dysfunction: A chronic condition? - Multimedia Presentation
Wednesday, 21 October 2009
SEWARD, AK, USA - Presented by Kenneth I. Glassberg, MD at the 107th Annual Meeting of the AUA - New York Section - August 19 - 26, 2009, Seward, Alaska, USA
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Comparison of ambulatory versus conventional urodynamics in females with urinary incontinence - Abstract
Tuesday, 20 October 2009
Departments of Obs/Gyn and PRM, University of Ankara, School of Medicine, Ankara, Turkey.
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AUA MA 2009 - Prostaglandin production by interstitial cells of Cajal regulates spontaneous rhythmic contraction of the urinary bladder - Session Highlights
Wednesday, 14 October 2009
WILLIAMSBURG, VA, USA (UroToday.com) - Detrusor smooth muscle has been shown to display spontaneous contractile activity during bladder filling.
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ICS 2009 - State of the Art Lecture: Bladder re-innervation: Can new nerves improve the function of the neurogenic bladder? - Session Highlights
Friday, 09 October 2009
SAN FRANCISCO, CA, USA (UroToday.com) - “Can new nerves improve the function of the neurogenic bladder?” was the main question addressed by Dr. William de Groat in his state of the art lecture.
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ICS 2009 - Unilateral sacral neuromodulation in patients with painful bladder syndrome/interstitial cystitis: 5 years follow up - Session Highlights
Friday, 09 October 2009
SAN FRANCISCO, CA, USA (UroToday.com) - The aim of this study was to evaluate the 5 year outcome data for patients with IC who underwent sacral neuromodulation (SNM) who had an initial good response (>50% improvement in one or more of the voiding parameters on voiding diary).
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ICS 2009 - Lower urinary tract symptoms in female patients with hyperthyroidism - Session Highlights
Thursday, 08 October 2009
SAN FRANCISCO, CA, USA (UroToday.com) - The purpose of this study was to investigate lower urinary tract symptoms (LUTS) in women with hyperthyroidism.
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ICS 2009 - Spun urinary sediments and Giemsa stain reveal a chronic inflammatory infiltrate in patients with symptoms of OAB - Session Highlights
Thursday, 08 October 2009
SAN FRANCISCO, CA, USA (UroToday.com) - Ruling out UTI in patients presenting with OAB symptoms is a vital step in the diagnostic process.
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ICS 2009 - Enhancing the detection of pyuria in fresh urine from patients with overactive bladder by use of the Sternheimer-Malbin stain - Session Highlights
Thursday, 08 October 2009
SAN FRANCISCO, CA, USA (UroToday.com) - This study looked at the enhanced diagnostic capabilities of the Sternheimer- Malbin stain for detecting wbc in the urine.
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ICS 2009 - Bacterial urinary tract infection in patients with OAB symptoms and negative midstream cultures exposed through culture of urinary spun sediment - Session Highlights
Thursday, 08 October 2009
SAN FRANCISCO, CA, USA (UroToday.com) - This study continued the line of thinking suggested in the three previous abstracts above: patients with symptomatic OAB have a relatively high rate of false negative urine cultures.
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ICS 2009 - Is ultrasound bladder wall thickness a better measure than urodynamics for overactive bladder symptoms? - Session Highlights
Thursday, 08 October 2009
SAN FRANCISCO, CA, USA (UroToday.com) - The relationship between OAB symptoms and objective diagnostic findings of OAB is not well defined.
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ICS 2009 - Subcapsular relocation for sacral neuromodulation pulse generator implant revision - Session Highlights
Thursday, 08 October 2009
SAN FRANCISCO, CA, USA (UroToday.com) - This technique was introduced as a method of revision for patients experiencing gluteal pain at the generator site after implantation.
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ICS 2009 - The role of industry funding in randomized controlled trials of antimuscarinic medications for overactive bladder - Session Highlights
Wednesday, 07 October 2009
SAN FRANCISCO, CA, USA (UroToday.com) - This study looked at the funding characteristics of randomized control trials (RCT) involving antimuscarinic medications for adult overactive bladder (OAB).
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ICS 2009 - National trends in the usage and success of sacral neuromodulation - Session Highlights
Wednesday, 07 October 2009
SAN FRANCISCO, CA, USA (UroToday.com) - Over 25,000 sacral neuromodulation systems (SNM) have been implanted world wide yet little is known about their mechanism of action, patterns of use, and outcomes.
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ICS 2009 - Smoking is independently associated with certain urinary storage symptoms: A population-based study - Session Highlights
Wednesday, 07 October 2009
SAN FRANCISCO, CA, USA (UroToday.com) - The impact of smoking on lower urinary tract symptoms (LUTS) is unclear.
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Urinary nerve growth factor but not prostaglandin E2 increases in patients with interstitial cystitis/bladder pain syndrome and detrusor overactivity - Abstract
Wednesday, 07 October 2009
Department of Urology, Buddhist Tzu Chi General Hospital, Hualien, Taiwan.
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Focus on Overactive Bladder

Focus on Overactive Bladder condenses a selection of compelling and relevant science - on topic and chosen by the UroToday.com editorial staff.

Podcast - Effective Darifenacin Treatment after Dissatisfaction with Prior Extended-Release Antimuscarinic Therapy

World Continence Week 2009

Patient Guide - Controlling Your Bladder Symptoms

- Prepared by Diane K. Newman, MSN, CRNP, FAAN, BCIA-PMDM

Promoting Continence Worldwide

- Prepared by Diane K. Newman, MSN, CRNP, FAAN, BCIA-PMDM

Urinary Incontinence: Epidemiology and Disease Burden
- Prepared by Alan J. Wein, MD, PhD (hon)

Differential Pharmacological Effects of Antimuscarinic Drugs on Heart Rate: A Randomized, Placebo-Controlled, Double-Blind, Crossover Study with Tolterodine and Darifenacin in Healthy Participants > or = 50 years
- by Brian Olshansky, MD

Darifenacin Treatment for Overactive Bladder in Patients Who Expressed Dissatisfaction With Prior Extended-Release Antimuscarinic Therapy
- by Norman Zinner, MD, et al.

Suburothelial Myofibroblasts in the Human Overactive Bladder and the Effect of Botulinum Neurotoxin Type A Treatment
- by Alexander Roosen, MD and Clare J. Fowler, MD

A Systematic Review and Meta-Analysis of Randomized Controlled Trials with Antimuscarinic Drugs for Overactive Bladder
- by Giacomo Novara, MD, FEBU

Emerging Drugs for Treatment of Overactive Bladder and Detrusor Overactivity
- by Marcus Drake, MD

Two Types of Urgency
- by Philip M. Hanno, MD, MPH - Editor's Pick

Long-Term Efficacy and Safety of Tolterodine in Children with Neurogenic Detrusor Overactivity
- by Pasquale Casale, MD

Defining Overactive Bladder as Hypersensitivity
- by Philip M. Hanno, MD, MPH

Minimally Invasive Therapy for Neurogenic Detrusor Overactivity: A Review
- by Karl-Erik Andersson, Roger Dmochowski and Alan Wein

A Randomized Controlled Study of Posterior Tibial Nerve Stimulation for Overactive Bladder
- by Paula Palma, MD, PhD. et al.

Efficacy and Tolerability of Add-On Trospium Chloride in Patients with Benign Prostate Syndrome and Overactive Bladder: A Noninterventional Trial Showing Use of Flexible Dosing
- by Ulrich Schwantes, PhD, et al.

The second-line management of idiopathic overactive bladder: What is the place of sacral neuromodulation and botulinum toxin-A in contemporary practice?

On the Origins of the Sensory Output from the Bladder: The Concept of Afferent Noise

A Review of Adherence to Drug Therapy in Patients with Overactive Bladder

Sacral Neuromodulation for Treating the Symptoms of Overactive Bladder Syndrome and Non-Obstructive Urinary Retention: More Than 10 Years of Clinical Experience

Urine cytokines suggest an inflammatory response in the overactive bladder: a pilot study
- by Michael Chancellor, MD, et al.

Obesity is associated with a more severe overactive bladder disease state that is effectively treated with once-daily administration of trospium chloride extended release
- by Michael G. Oefelein, MD, et al.

Ten years single surgeon experience with botulinum toxin in the urinary tract; clinical observations and research discovery
- by Michael Chancellor, MD.

The evolution of transdermal therapy for overactive bladder
- by Peter K. Sand, MD

Outcome of a Randomized, Double-Blind, Placebo Controlled Trial of Botulinum A Toxin for Refractory Overactive Bladder
- by Michael K. Flynn, MD, et al.

InterStim Therapy: A Contemporary Approach to Overactive Bladder
- by Neeraj Kohli, MD, MBA and Danielle Patterson, MD

Differential Pharmacological Effects of Antimuscarinic Drugs on Heart Rate: A Randomized, Placebo-Controlled, Double-Blind, Crossover Study with Tolterodine and Darifenacin in Healthy Participants > or = 50 years
- by Brian Olshansky, MD, et al.

Randomized Comparison of Tolterodine With Vaginal Estrogen Cream Versus Tolterodine Alone for the Treatment of Postmenopausal Women With Overactive Bladder Syndrome
- by Ling-Hong Tseng, MD, et al.

The role of industry funding in randomized controlled trials of antimuscarinic medications for overactive bladder
- Session Highlight by Ariana L. Smith, MD from the International Continence Society (ICS) 39th Annual Meeting

State of the Art Lecture: Bladder re-innervation: Can new nerves improve the function of the neurogenic bladder?
- Session Highlight by Ariana L. Smith, MD from the International Continence Society (ICS) 39th Annual Meeting

Is ultrasound bladder wall thickness a better measure than urodynamics for overactive bladder symptoms?
- Session Highlight by Ariana L. Smith, MD from the International Continence Society (ICS) 39th Annual Meeting

Urodynamics/Incontinence/Female Urology: Urodynamic Testing - Identification of Measures of Bladder Sensation in Patients with Overactive Bladder
- Session Highlight by Kathleen Kobashi, MD from the 2009 Annual Meeting of the American Urological Association (AUA)

Session Highlights from the Society for Urodynamics & Female Urology 2009 Winter Meeting
- Exclusive Coverage by UroToday Contributing Medical Editor, William Jaffe, MD

The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) at The National Institutes of Health (NIH) - UI Symposium
- Session Highlights Reported by Diane K. Newman

Drug Treatment - Lecture Series

- Presented by Karl-Erik Andersson, MD, PhD, and Christopher Chapple, MD, et al. at the Fourth International Consultation on Incontinence (ICI)

Drug Treatment - Committee Meeting Highlights

- Reported by William Jaffe, MD from the Fourth International Consultation on Incontinence (ICI)

Voiding Dysfunction Session Highlights

- From the American Urological Association 2008 Annual Meeting

Urodynamics and Reality

- Presented by Ed McGuire, MD, at the 32nd Winter Urologic Forum

Clinical Proof of Concept Study (BLOSSOM) Shows Novel Beta 3 Adrenoceptor Agonist YM178 is Effective and Well Tolerated in the Treatment of Symptoms of Overactive Bladder
- Presented at the European Association of Urology - 23rd Annual EAU Congress

International Consultation on Incontinence - ICI 2008
- Session Abstracts, Overactive Bladder