ANAHEIM, CA (UroToday.com) - The authors utilized SEER data to analyze outcomes in 2,569 patients with non-metastatic disease at presentation who underwent either radical cystectomy or radiation therapy. They then grouped patients into sub groups by age and analyzed survival data to identify whether radical cystectomy offered the same benefit across all age groups. The authors found that the survival benefit with cystectomy over radiation was greater in the 60-69 and 70-79 age groups (median disease specific survival 62 months with radiation therapy versus not reached in the cystectomy group for both). When patients in the 80-89 age group were analyzed (455 treated with radiation and 502 treated with cystectomy) they found a median disease specific survival of 33 months with radiation therapy and 70 months with radical cystectomy. Notably however, in patients older than 80 years of age, the overall survival benefit was lower since median overall survival in the radical cystectomy group was 22 months compared to 16 months in patients treated with radiation therapy. The authors thus concluded that while all age groups derive an overall and cancer-specific survival benefit following a radical cystectomy, this benefit is . smaller in octogenarians than for younger patients.

( ABST [1516] )

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Written by Ashish M. Kamat, a Contributing Editor with UroToday.

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