Beyond the Abstract - N-acetyltransferase-2 gene polymorphisms and prostate cancer susceptibility in Latin American patients, by Leonardo Oliveira Reis, MD, MSc, PhD

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BERKELEY, CA (UroToday.com) - Based on the rationale that individuals incapable of adequately detoxifying a toxic agent or a metabolic carcinogen would undergo more DNA and cell damage with the formation of adducts or chemical elements bound to DNA and protein macromolecules, genomic instability and, consequently, would have a greater risk of developing tumors, N-acetyltransferases (NAT2) are particularly interesting because they are believed to be pivotal to the activation of aromatic or heterocyclic amines, metabolizing important carcinogenic products directly involved in the tumor initiation process.