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Categories Investigative Urology Differences in the brain penetration of the anticholinergic drugs trospium chloride and oxybutynin - Abstract
Differences in the brain penetration of the anticholinergic drugs trospium chloride and oxybutynin - Abstract
Published on 01 August 2012
INTRODUCTION: This study was performed to compare tissue distribution and brain penetration of the anticholinergic drugs trospium chloride and oxybutynin in a mouse model. Additionally, the role of the drug efflux carrier P-glycoprotein for hepatobiliary and urinary excretion and the blood-brain barrier permeability of oxybutynin were evaluated by using knockout mice that were deficient in P-glycoprotein.
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