Investigative Urology

Chronobiology of micturition: Putative role of the circadian clock - Abstract

Published on Tuesday, 14 May 2013 15:19

PURPOSE: Mammals urinate less frequently during sleep period than during awake period, which is modulated by triad factors; decreased arousal level in the brain, decreased urine production rate from the kidneys, and increased functional bladder capacity during sleep.

Arrested spermatogenesis and evidence for DNA damage in PTIP mutant testes - Abstract

Published on Tuesday, 14 May 2013 15:15

The differentiation of mature sperm from male germ cells requires both chromatin remodeling and compaction as well as DNA double stranded break repair of sister chromatids.

Seminal plasma glycoproteins in male infertility and prostate diseases: Is there a chance for glyco-biomarkers? - Abstract

Published on Tuesday, 14 May 2013 15:06

CONTEXT: Disturbed protein-carbohydrate interactions may underlie the molecular mechanism of some diseases of the male reproductive tract, including infertility and prostate diseases.

High resolution X chromosome-specific array-CGH detects new CNVs in infertile males - Abstract

Published on Tuesday, 14 May 2013 14:46

CONTEXT: The role of CNVs in male infertility is poorly defined, and only those linked to the Y chromosome have been the object of extensive research.

RAB-like 2 has an essential role in male fertility, sperm intra-flagellar transport, and tail assembly - Abstract

Published on Tuesday, 14 May 2013 14:41

A significant percentage of young men are infertile and, for the majority, the underlying cause remains unknown.

The protease activated receptor 1 gene variation IVSn -14A >T is associated with distant metastasis and cancer-specific survival in renal cell carcinoma - Abstract

Published on Tuesday, 14 May 2013 14:37

OBJECTIVE: Protease activated receptor 1 (PAR-1) mediates angiogenesis and impacts the process of tumor growth and disease progression.

An investigation of risk factors for renal cell carcinoma by histologic subtype in two case-control studies - Abstract

Published on Monday, 13 May 2013 16:27

To investigate whether renal cell carcinoma (RCC) histologic subtypes possess different etiologies, we conducted analyses of established RCC risk factors by subtype (clear cell, papillary and chromophobe) in two case-control studies conducted in the United States (1,217 cases, 1,235 controls) and Europe (1,097 cases, 1,476 controls).

Constitutional genetic variants as predictors of antiangiogenic therapy outcome in renal cell carcinoma - Abstract

Published on Monday, 13 May 2013 16:23

The development of specific angiogenesis inhibitors has drastically improved renal cancer treatment in recent years.

Inhibition of mTORC2 but not mTORC1 up-regulates E-cadherin expression and inhibits cell motility by blocking HIF-2α expression in human renal cell carcinoma - Abstract

Published on Monday, 13 May 2013 15:35

PURPOSE: Molecular targeted drugs, such as mTORC1 inhibitors, have been clinically popularized for advanced renal cell carcinoma treatment but metastasis is still a serious concern.

Autocrine stimulation of clear-cell renal carcinoma cell migration in hypoxia via HIF-independent suppression of thrombospondin-1 - Abstract

Published on Monday, 13 May 2013 15:29

Thrombospondin-1 is a matricellular protein with potent antitumour activities, the levels of which determine the fate of many different tumours, including renal carcinomas.

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