Investigative Urology

Predicting high risk disease using serum and DNA biomarkers - Abstract

Published on Friday, 17 May 2013 08:57

PURPOSE OF REVIEW: To explore several serum and genetic-based biomarkers that may prove useful in following men being managed with active surveillance for localized prostate cancer by predicting those that either have the potential to develop, or already harbor occult high grade disease.

Marked improvement of cytotoxic effects induced by docetaxel on highly metastatic and androgen-independent prostate cancer cells by downregulating macrophage inhibitory cytokine-1 - Abstract

Published on Friday, 17 May 2013 08:52

BACKGROUND: Overexpression of macrophage inhibitory cytokine-1 (MIC-1) frequently occurs during the progression of prostate cancer (PC) to androgen-independent (AI) and metastatic disease states and is associated with a poor outcome of patients.

Bcl-2 associated athanogene 5 (Bag5) is overexpressed in prostate cancer and inhibits ER-stress induced apoptosis - Abstract

Published on Friday, 17 May 2013 08:43

BACKGROUND: The Bag (Bcl-2 associated athanogene) family of proteins consists of 6 members sharing a common, single-copied Bag domain through which they interact with the molecular chaperone Hsp70.

In vitro model systems to study androgen receptor signaling in prostate cancer - Abstract

Published on Friday, 17 May 2013 08:37

Prostate cancer (PCa) is one of the most common causes of male cancer-related death in Western nations.

Establishment of a mouse model bearing spinal metastatic human prostate cancer using fluorescence-labeled PC-3 cells - Abstract

Published on Thursday, 16 May 2013 14:13

OBJECTIVE: To establish a mouse model of spinal metastasis of human prostate cancer using fluorescence-labeled PC-3 cells to allow direct observation by in vivo imaging.

Crude saponins from Platycodon grandiflorum induce apoptotic cell death in RC-58T/h/SA#4 prostate cancer cells through the activation of caspase cascades and apoptosis-inducing factor - Abstract

Published on Thursday, 16 May 2013 14:08

Saponins are a major active component of Platycodon grandiflorum (P. grandiflorum) and are known to induce apoptosis in metastatic prostate cancer cell lines.

Quantitative proteomics reveals that enzymes of the ketogenic pathway are associated with prostate cancer progression - Abstract

Published on Thursday, 16 May 2013 14:01

Prostate cancer is the most common malignancy and the second leading cause of cancer-related deaths in men.

Epigenetic reactivation of Nrf2 in murine prostate cancer TRAMP C1 cells by natural phytochemicals Z-Ligustilide and Radix Angelica Sinensis via promoter CpG demethylation - Abstract

Published on Thursday, 16 May 2013 13:56

Cancer development has been linked to epigenetic modifications of cancer oncogenes and tumor suppressor genes; in advanced metastatic cancers, severe epigenetic modifications are present.

Flavanols from Japanese quince (chaenomeles japonica) fruit inhibit human prostate and breast cancer cell line invasiveness and cause favorable changes in bax/bcl-2 mRNA ratio - Abstract

Published on Thursday, 16 May 2013 13:49

Polyphenols are natural compounds of high structural diversity which translates into a very wide spectrum of biological activities, including chemoprevention.

Ginger phytochemicals exhibit synergy to inhibit prostate cancer cell proliferation - Abstract

Published on Thursday, 16 May 2013 13:34

Dietary phytochemicals offer nontoxic therapeutic management as well as chemopreventive intervention for slow-growing prostate cancers.

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