Saponins are a major active component of Platycodon grandiflorum (P. grandiflorum) and are known to induce apoptosis in metastatic prostate cancer cell lines.
Prostate cancer is the most common malignancy and the second leading cause of cancer-related deaths in men.
Cancer development has been linked to epigenetic modifications of cancer oncogenes and tumor suppressor genes; in advanced metastatic cancers, severe epigenetic modifications are present.
Polyphenols are natural compounds of high structural diversity which translates into a very wide spectrum of biological activities, including chemoprevention.
Dietary phytochemicals offer nontoxic therapeutic management as well as chemopreventive intervention for slow-growing prostate cancers.
BACKGROUND: Ecological and epidemiological studies have identified an inverse association of intensity and duration of sunlight exposure with prostate cancer, which may be explained by a reduction in vitamin D synthesis.
Prostate cancer is the most common visceral malignancy and the second leading cause of cancer deaths in US men.
BACKGROUND: Myxovirus (influenza virus) resistance A (MxA) is an interferon stimulated antiviral protein that is required for a complete antiviral response.
Multidrug resistance is a major cause of chemotherapy failure.
Concurrent activation of RAS/ERK and PI3K/AKT pathways is implicated in prostate cancer progression.
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