Investigative Urology

CCN3 promotes prostate cancer bone metastasis by modulating the tumor-bone microenvironment through RANKL-dependent pathway - Abstract

Published on Wednesday, 22 May 2013 15:24

Bone metastasis in patient with advanced-stage prostate cancer, the most commonly diagnosed malignancy in Western countries, increases the risk of intractable bone pain.

Trop-2 promotes prostate cancer metastasis by modulating β1 integrin functions - Abstract

Published on Wednesday, 22 May 2013 15:20

The molecular mechanisms underlying metastatic dissemination are still not completely understood.

Interleukin-1β promotes skeletal colonization and progression of metastatic prostate cancer cells with neuroendocrine features - Abstract

Published on Wednesday, 22 May 2013 15:11

Despite the progress made in the early detection and treatment of prostate adenocarcinoma, the metastatic lesions from this tumor are incurable.

Development and validation of a 32-gene prognostic index for prostate cancer progression - Abstract

Published on Wednesday, 22 May 2013 15:07

The accurate determination of the risk of cancer recurrence is an important unmet need in the management of prostate cancer.

Response of the insulin-like growth factor (IGF) system to IGF-IR inhibition and androgen deprivation in a neoadjuvant prostate cancer trial: Effects of obesity and androgen deprivation - Abstract

Published on Wednesday, 22 May 2013 15:04

Context: Prostate cancer patients at increased risk for relapse after prostatectomy were treated in a neoadjuvant study with androgen deprivation therapy (ADT) in combination with cixutumumab, an inhibitory fully human monoclonal antibody against IGF receptor 1 (IGF-IR).

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine - Abstract

Published on Wednesday, 22 May 2013 14:57

Expressed prostatic secretions (EPS) are proximal fluids of the prostate that are increasingly being utilized as a clinical source for diagnostic and prognostic assays for prostate cancer (PCa).

Metabolic reprogramming and validation of hyperpolarized 13 C lactate as a prostate cancer biomarker using a human prostate tissue slice culture bioreactor - Abstract

Published on Wednesday, 22 May 2013 14:53

BACKGROUND: The treatment of prostate cancer has been impeded by the lack of both clinically relevant disease models and metabolic markers that track tumor progression.