Erectile Dysfunction

Recent advances in the treatment of neurogenic erectile dysfunction - Abstract

Neurogenic erectile dysfunction (ED) can be broadly defined as an inability to sustain or maintain a penile erection owing to a neurological impairment, either centrally or peripherally or both.


Evaluating the efficacy of vacuum constrictive device and causes of its failure in impotent patients - Abstract

PURPOSE: This study evaluates the efficacy of Vacuum constrictive device (VCD) and the reasons for its failure.


Lower urinary tract symptoms and erectile dysfunction in men with type 2 diabetes mellitus - Abstract

PURPOSE: To assess the prevalence of lower urinary tract symptoms (LUTS) and erectile dysfunction (ED) and the relationships between LUTS, ED, depression, and other factors in Korean men with type 2 diabetes mellitus (T2DM).


Effects of testosterone supplementation on prevention of age-related penile remodeling - Abstract

Erectile dysfunction develops among 46.2% of men between 40 and 70 years.

Studies demonstrated substitution on detrusor muscle by collagen due testosterone deprivation. It is clear the correlation among aging and oxidative stress, accelerating apoptosis process in many tissues. This study aims to demonstrate the collagen substitution over the muscle fibers on muscle structure of rat's penis and the effects of testosterone supplementation. Sixteen senescent Wistar rats were divided into two groups: treatment (receiving standard supplementation testosterone dose) and control (receiving equivalent saline solution). Testosterone was dosed on D0 and D56 of study. All penises were prepared with picrosirius colored histology; stereology was applied to determine the volumetric density of collagen fibers (Vv). Analysis of variance demonstrated testosterone group's replacement therapy to be effective, while the androgenic decline continued by the time of experiment in control group (p < 0.05). Testosterone group had Vv of 20.6%, lower than control group (47.8%); t-test (p < 0.001). Pearson's correlation demonstrated an inverse correlation between the Vv and testosterone's levels (p < 0.001). This is a pioneer study on demonstration of structural alterations over the cavernous corpora muscle caused by deprivation of testosterone on elderly rat. These finding implicate that the testosterone levels can influence, not only the libido, but also the erectile function.

Written by:
Ferreira FT, Dambros M, Bisogni S, Dambros MC, Scolfaro MR, Palma PC.   Are you the author?
Discipline of Urology, Department of General Surgery, Campinas State University , Campinas , Brazil .

Reference: Aging Male. 2014 Mar;17(1):12-7
doi: 10.3109/13685538.2013.873784

PubMed Abstract
PMID: 24397689



Erectile function restoration after repair of resected cavernous nerves by adipose-derived stem cells combined with autologous vein graft in rats - Abstract

Cavernous nerve (CN) injury is the main cause of erectile dysfunction (ED) following radical prostatectomy.


Tadalafil treatment had a modest effect on endothelial cell damage and repair ability markers in men with erectile dysfunction and vascular risk - Abstract

The number of the circulating angiogenic cells (CACs) and colony forming units (CFUs) derived from cultured circulating mononuclear cells (MNCs) represents a laboratory surrogate for endothelial cell repair ability.


Endocrine evaluation of erectile dysfunction - Abstract

Erectile dysfunction is highly prevalent, affecting up to half of men in their 50-70s, and has been variably associated to a variety of causes including unhealthy lifestyles, such as smoking or overweight, or comorbidities such as hypertension, diabetes mellitus, and neurological disorders.


Long-term testosterone treatment in elderly men with hypogonadism and erectile dysfunction reduces obesity parameters and improves metabolic syndrome and health-related quality of life - Abstract

INTRODUCTION: Late-onset hypogonadism (LOH) is diagnosed when declining testosterone concentrations in the aging male cause unwanted symptoms such as erectile dysfunction (ED), reduced bone density and muscle strength, and increased visceral obesity.


Improving sexual health in men with prostate cancer: Randomised controlled trial of exercise and psychosexual therapies - Abstract

BACKGROUND: Despite being a critical survivorship care issue, there is a clear gap in current knowledge of the optimal treatment of sexual dysfunction in men with prostate cancer.


Association between erectile dysfunction and echocardiographic variables of ventricular hypertrophy and diastolic function in hypertensive patients with type 2 diabetes mellitus: A cross-sectional study - Abstract

BACKGROUND: This study was conducted among individuals with diabetes and hypertension in order to assess the prevalence of erectile dysfunction (ED) and the association between ED and cardiovascular risk variables such as echocardiographic changes.


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