Oncologia Medica, ASO S. Croce e Carle, Cuneo, Italy.

To evaluate the effects of the association between docetaxel and the somatostatin analogue lanreotide on the androgen-independent prostate cancer cell line PC3, either sensitive or made resistant to docetaxel (PC3R), as new drugs and new combinations have promising clinical activity in hormone-refractory prostate cancer.

We examined the effect of docetaxel and lanreotide on cell proliferation, with analysis of the mitogen-activated protein kinase pathway and expression of cell-cycle regulatory proteins.

Combined treatment with docetaxel and lanreotide inhibited PC3 cell growth in vitro through an enhanced induction of cell death, compared with treatment with either agent alone; this result was particularly evident on PC3R cells. The results suggested that lanreotide could act as a P glycoprotein inhibitor in PC3R cells.

The present results provide a promising therapeutic approach for using somatostatin analogues in hormone-refractory prostate cancer, in which lanreotide could interact with docetaxel in PC3R cells, with possible explanatory mechanisms which involve P glycoprotein-mediated docetaxel resistance.

Written by
Lo Nigro C, Maffi M, Fischel JL, Formento P, Milano G, Merlano M.

Reference
BJU Int. 2008 May 19. Epub ahead of print.
doi:10.1111/j.1464-410X.2008.07706.x

PubMed Abstract
PMID:18494832

UroToday.com Prostate Cancer Section

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