Tokyo Kosei Nenkin Hospital, Department of Urology, 5-1 Tsukudo-cho, Shinjuku-ku, Tokyo 162-8543, Japan

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Evaluation of: Spiotto MT, Hancock SL, King CR: Radiotherapy after prostatectomy: improved biochemical relapse-free survival with whole pelvic compared with prostate bed only for high-risk patients.Int. J. Radiat. Oncol. Biol. Phys.69, 54-61 (2007). Although most patients with localized prostate cancer are successfully treated with radical prostatectomy, high-risk patients often manifest biochemical and/or clinical relapse. Adjuvant or salvage radiotherapy is utilized for the treatment of these patients. For definitive radiotherapy for untreated prostate cancer, a randomized clinical study (radiation therapy oncology group [RTOG] 94-13), suggested superior effects of whole-pelvic radiotherapy to prostate-only radiotherapy. On the contrary, for adjuvant or salvage radiotherapy after radical prostatectomy, the role of whole-pelvic radiotherapy has not been extensively investigated. This retrospective study demonstrated better biochemical relapse-free survival in high-risk patients receiving adjuvant or salvage whole-pelvic radiotherapy, when combined with concurrent hormonal therapy, compared with prostate bed radiotherapy. Selection for good candidates for whole-pelvic radiotherapy after radical prostatectomy will be confirmed in future and a large-scale randomized clinical trial is required before the final conclusion can be made.

Written by
Akakura K.

Reference
Future Oncol. 2007 Dec;3(6):613-6
doi:10.2217/14796694.3.6.613

PubMed Abstract
PMID:18041913

UroToday.com Prostate Cancer Section

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