Department of Medical Physics, Memorial Sloan-Kettering Cancer Center, New York, NY.

To use radiation exposure rate measurements to determine patient-specific radiation safety instructions with the aim of reducing unnecessary precaution times and to evaluate potential doses to members of the public.

Radiation exposure rate measurements were obtained from 1279 patients with Stage T1-2 prostate cancer who underwent transperineal (125)I or (103)Pd seed implantation from January 1995 through July 2008. An algorithm was developed from these measurements to determine the required precaution times to maintain public effective doses below 50% of the limits for specific exposure situations.

The median air kerma rates at 30cm from the anterior skin surface were 4.9muGy/h (range: 0.1-31.5) for (125)I and 1.5muGy/h (range: 0.02-14.9) for (103)Pd. The derived algorithms depended primarily on the half-life T(p), the measured exposure rate at 30cm, and specific exposure situation factors. For the typical (103)Pd patient, no radiation safety precautions are required. For the typical (125)I patient, no precautions are required for coworkers, nonpregnant adults who do not sleep with the patient, or nonpregnant adults who sleep with the patient. Typical (125)I patients should only avoid sleeping in the "spoon" position (i.e., in contact) with pregnant adults and avoid holding a child for long periods of time in the lap for about 2 months.

The large number of cases available for this study permitted the development of an algorithm to simply determine patient-specific radiation safety instructions. The resulting precaution times are significantly less restrictive than those generally prescribed currently.

Written by:
Dauer LT, Kollmeier MA, Williamson MJ, St Germain J, Altamirano J, Yamada Y, Zelefsky MJ.   Are you the author?

Reference:
Brachytherapy. 2009 Oct 21. Epub ahead of print.
doi:10.1016/j.brachy.2009.06.006

PubMed Abstract
PMID:19853532

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