ANAHEIM, CA (UroToday.com) - The UC San Francisco group of investigators (Abstract 1362) provide further evidence linking stone disease to atherosclerotic vascular disease. These investigators previously hypothesized that the initial stone event may be vascular in origin and therefore they performed a prospective analysis of 45, 988 men in the Health Professionals Follow-up Study to determine if those patients with a history of stone disease subsequently developed cardiovascular disease. From the study group 4,747 (10%) patients had a history of stone disease at baseline. After adjusting for cofounders the multivariate relative risk was significantly increased for development of coronary heart disease, myocardial infarction, angina and coronary artery bypass graft surgery. There was no increased risk of stroke. Although these were modest increased risks they were statistically significant. The real question remains whether the observed peri-microvascular calcifications associated with calcium oxalate stone disease is the primary or secondary event in these stone forming patients. These observations warrant further investigation and evaluation.

( ABST [1362] ) Nephrolithiasis and the Risk of Cardiovascular Disease

UroToday.com Full Conference Reports

Written by Elspeth M. McDougall, MD, a Contributing Editor with UroToday.

Please log-in or register in order to submit comments.

Powered by AkoComment!