We evaluated the prognosis of patients with locally advanced RCC and identified a new model to stratify their outcome.

We analyzed the data of 227 patients who had undergone partial or radical nephrectomy for pT3–4 RCC at two academic centers between 1986 and 2002. The log-rank test and Cox proportional hazards model were used for univariate and multivariate analysis, respectively.

At a median follow-up of 29 mo, we censored 108 (47.6%) cancer-related deaths. On univariate analysis, the 2002 T stage was not statistically significant. According to cancer-related outcome, we identified three subgroups of patients with different prognoses: pT3a(n): tumors with perirenal fat invasion or renal vein thrombosis or thrombosis within the vena cava below the diaphragm; pT3b(n): tumors with renal vein thrombosis or thrombosis within the vena cava below the diaphragm and concomitant perirenal fat invasion; pT4(n): adrenal gland or Gerota fascia invasion or thrombosis within the vena cava above the diaphragm. The three subgroups had significantly different prognoses. The new reclassification was an independent predictive variable on multivariate analysis, as well as the pathologic lymph node stage.

The 2002 version of TNM of locally advanced RCC did not stratify patient outcome. The present study suggests the possibility of reclassifying pT3–4 RCC into three categories capable of predicting cancer-specific survival, regardless of all other prognostic factors.

Vincenzo Ficarra, Giacomo Novara, Massimo Iafrate, Livio Cappellaro, Emiliano Bratti, Filiberto Zattoni, Walter Artibani

Department of Urology, University of Verona, Verona, Italy
Department of Oncological and Surgical Sciences, Urology Clinic, University of Padua, Padua, Italy

Accepted 12 July 2006 published online 31 July 2006.