ANAHEIM, CA (UroToday.com) - (ABST#211 - Kidney Cancer Basic Research I) Aberrant hypermethylation of Wnt-antagonist genes contribute to the pathogenesis of many cancers. The authors investigated this phenomenon in RCC. They examined promoter methylation using methylation specific PCR in tumor samples and serum samples from 62 patients with RCC. They developed a methylation score to reflect the degree of methylation of 6 Wnt antagonist genes. They found that increased methylation score was associated with a worse prognosis in patients with RCC and that serum samples could also be used to detect Wnt antagonist hypermethylation.

Urakami S et al., Japan

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Written by Christopher G. Wood, MD, a Contributing Editor with UroToday.

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