CANCUN, MEXICO (UroToday.com) - Coverage of the 25th Annual World Congress of Endourology and SWL - Cancun, Mexico - Thursday November 1, 2007

Ureteroscopy often induces supraphysiological ureteral and renal pelvic pressures and this may lead to septic complications and bleeding. Jung and colleagues from Denmark studied the effects of ureteral irrigation with isoproterenol in a porcine model. There were 12 study pigs and 10 control pigs. Isoproterenol was instilled via ureteroscope at a concentration of 0.1 ug/mL and at a rate of 8 mL/min.

The control group was ureteral irrigation with normal saline. Renal pelvic and bladder pressures were measured with catheters. During ureteroscopy, mean renal pelvic pressure rose to 26 ± 2.3 mmHg in the isoproterenol group, while the mean control pelvic pressure was 38 ± 3.1 mmHg (p<0.001). This work further supports the discovery of intra-ureteral medications to decrease ureteral inflammation and improve patient morbidity after ureteroscopy.

Session: Ureteroscopy/Retrograde Intrarenal Surgery
Moderators: Yoram I. Siegel (USA), Petrisor Geavlete (Romenia)
Helene Jung, Joern Jakobsen, Jens Mortensen, Palle Joern Osther, Jens Christian Djurhuus

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