Russian Research Center for Endocrinology, Moscow, Russia.

This email address is being protected from spam bots, you need Javascript enabled to view it

Elderly men are bothered by lower urinary tract complaints designated as lower urinary tract symptoms (LUTS). In epidemiological studies LUTS appears strongly associated with erectile dysfunction, and also with metabolic syndrome. LUTS occurs at an age at which plasma testosterone levels decline, in some men to hypogonadal values. Objectives. This pilot study tested whether testosterone administration to elderly men complaining of LUTS and whose plasma testosterone levels are below normal, might alleviate LUTS.

Group 1 (n = 10) received treatment with testosterone gel (50 mg) daily for three months; group 2 (n = 20) received treatment with injections of testosterone undecanoate 1000 mg for 26 weeks.

Upon these interventions, plasma testosterone increased to the normal range. Symptoms of LUTS, measured by the International Prostate Symptoms Score, improved significantly, and also scores of the Aging Males' Symptoms scale and international index of erectile function improved. There were no untoward effects on the prostate over this period of time of the study.

Testosterone administration improved symptoms of LUTS in men with late-onset hypogonadism. The mechanism of action is as yet not understood, but it may be connected with or parallel with the effects of testosterone on penile tissues in hypogonadal men, such as on nitric oxide and phosphodiesterase.

Written by
Kalinchenko S, Vishnevskiy EL, Koval AN, Mskhalaya GJ, Saad F.

Reference
Aging Male. 2008 Jun;11(2):57-61.
doi:10.1080/13685530801953994

PubMed Abstract
PMID:18570056

UroToday.com BPH and Male LUTS Section

Please log-in or register in order to submit comments.

Powered by AkoComment!