Urology & Nephrology Center, Mansoura University, Mansoura, Egypt.

To compare the functional results from a prospective randomized trial of two different reflux-prevention techniques for ileal bladder substitution.

In all, 60 patients with invasive bladder cancer were randomized to receive either a serous-lined extramural tunnel (group 1) or T-limb ileal procedure (group 2) as an antireflux technique for the ileal substitute. The preoperative evaluation included intravenous urography, radioisotope renography to evaluate glomerular filtration rates (GFRs) and renal cortical imaging with (99m)Tc- dimercaptosuccinic acid to assess parenchymal scarring. Evaluable patients were re-assessed by the same imaging, and by ascending studies.

The follow-up included 27 patients (49 units) in group 1 and 23 (45 units) in group 2, with a mean (sd) follow-up of 6.3 (0.5) and 7.4 (1.9), respectively. Uretero-ileal strictures were diagnosed in one renal unit in each group (P = 0.5). Ascending studies showed no reflux in any patients in group 1, while 13 renal units (29%) in group 2 were refluxing (P < 0.01). There was progressive cortical scarring with or with no significant reduction in GFR (>25%) in three and four renal units in groups 1 and 2, respectively. Among the 13 refluxing units in group 2, three showed a significant deterioration in GFR and one renal unit was diagnosed with progressive cortical scarring.

Both procedures provided a low rate of anastomotic stricture, with acceptable preservation of renal function. The serous-lined extramural tunnel provided a more effective antireflux mechanism.

Written by:
Osman Y, Abol-Enein H, El-Mekresh M, Gad H, Elhefnawy A, Ghoneim M.   Are you the author?

Reference:
BJU Int. 2009 Apr 17. Epub ahead of print.
doi: 10.1111/j.1464-410X.2009.08574.x

PubMed Abstract
PMID:19388994

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