Department of Urology, Sapporo Medical University School of Medicine, Sapporo, Japan

Hematopoietic cell transplantation is a key treatment to prolong patient survival for many hematological disorders. Renal impairment is well recognized as a significant complication of hematopoietic cell transplantation, which can progress to end-stage renal disease. Herein, we report our experience of two patients who underwent renal transplantation from the same donor who provided cells for the preceding hematopoietic cell transplantation. One patient had undergone peripheral blood stem cell transplantation with a non-myeloablative conditioning regimen, whereas the other had received bone marrow transplantation with a myeloablative regimen. Chronic immunosuppressive therapy was not needed in either one to maintain the kidney graft function. Not only bone marrow transplantation with a myeloablative conditioning regimen, but also peripheral blood stem cell transplantation with a non-myeloablative regimen can confer immunological tolerance.

Written by
Tanaka T, Ishida H, Shirakawa H, Amano H, Nishida H, Tanabe K

Reference
Int J Urol. 2007 Nov;14(11):1044-5
doi:10.1111/j.1442-2042.2007.01877.x

PubMed Abstract
PMID:17956534

UroToday.com Renal Transplantation, Vascular Disease Section

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