CANCUN, MEXICO (UroToday.com) - Coverage of the 25th Annual World Congress of Endourology and SWL - Cancun, Mexico - Wednesday October 31st 2007

The authors investigated the uric acid metabolism during non-carbonic acid loading in idiopathic calcium nephrolithiasis and healthy subjects. This was a randomized placebo controlled, cross-over study including 12 male idiopathic stone formers and 12 healthy males. They found no difference in the serum urate concentrations between the two groups. Likewise, these values were unaffected by NH4Cl acidosis. The renal excretion of uric acid in healthy individuals decreased progressively in response to NH4Cl loading while it increased in calcium stone formers. This study suggests the possible lithogenic capability of protein loading in patients with calcium stones.

This study lends credence to existing data that serum uric concentrations are not reliable predictors of increased renal uric acid excretion and its association with calcium stone formation. Further studies focusing on the cellular mechanisms of urate transport are however necessary to validate this finding.

Session: Stones: Metabolism and Medical Treatment
Moderators: Dean Assimos (USA), Frank Keeley (UK)
Palle Oster - Department of Urology, Fredericia and Kolding Hospitals

UroToday.com Full Conference Coverage

Reported by UroToday.com Contributing Editor Aldrin Joseph R. Gamboa, MD

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