CANCUN, MEXICO (UroToday.com) - Coverage of the 25th Annual World Congress of Endourology and SWL - Cancun, Mexico - Wednesday October 31st 2007

The authors described for the first time a possible causative mechanism for phenytoin in calculus stone formation. Although this is just a single case report, interestingly, they were able to document phenytoin metabolites in the chemical stone analysis.

The previously documented potential effects of phenytoin on the genitourinary system such as interstitial nephritis, priapism, nephrotic syndrome and acute renal failure have been described previously in literature. This presentation describes the potential lithogenic ability of chronic phenytoin use.

The remarkable feature of this study is that it should arouse the clinician’s level of suspicion once he is confronted with symptomatic patients with renal calculi who have a significant history of phenytoin use.

Session: Stones: Metabolism and Medical Treatment
Moderators: Dean Assimos (USA), Frank Keeley (UK)
Carmin Kalorin, Rass Bauer, Mark White Albany Medical Center

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Reported by UroToday.com Contributing Editor Aldrin Joseph R. Gamboa, MD

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