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IC/PBS/BPS/HBS

UroToday's IC/PBS/BPS section is a repository of the clinical publications, clinical trials and investigative science pertaining to the diagnosis and treatment of interstitial cystitis/painful bladder syndrome/bladder pain syndrome. Also available are conference coverage for all timely IC/PBS/BPS, audio podcasts and downloadable slides from UroToday's slide library.

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Lack of Efficacy of Pentosan Polysulfate in Some Patients May be Partially Explained by Poor Urinary Excretion
Wednesday, 02 August 2006
BERKELEY, CA (UroToday.com) - Pentosan Polysulfate (PPS) is the only oral medication approved by the United States Food and Drug Administration for interstitial cystitis.
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Microscopic Hematuria Common Finding in Patients with PBS/IC
Monday, 17 July 2006
BERKELEY, CA (UroToday.com) - Painful Bladder Syndrome / Interstitial Cystitis is commonly associated with the finding of microhematuria. Stanford and colleagues evaluated 100 female patients with interstitial cystitis with a potassium sensitivity test, cystoscopy under anesthesia and bladder distention, and pelvic pain and urgency frequency (PUF) score.
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Resiniferatoxin (RTX) May Improve Lower Urinary Tract Symptoms
Thursday, 13 July 2006
BERKELEY, CA (UroToday.com) - Fifteen patients were recruited for an open label study to evaluate the safety and efficacy of a single administration of 100ml of 50nM RTX freshly dissolved in 10% ethanol in saline and administered via intravesical catheter over 2-4 minutes.
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Lower Urinary Tract Symptoms in Female Patients with Rheumatoid Arthritis
Thursday, 06 July 2006
Berkeley, CA (UroToday.com) - Patients with systemic lupus erythematosus (SLE), Sjögren's syndrome (SS), and Graves disease are reported to be associated with an increased severity of LUTS compared with control populations.
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An Outsider’s View Of Chronic Fatigue Syndrome May Provide Clues To How We Perceive PBS/IC
Wednesday, 28 June 2006
BERKELEY, CA (UroToday.com) - Lee Nyberg of the National Institute of Diabetes, Digestive, and Kidney Diseases (NIDDK) pointed out a very interesting manuscript by Mark Demitrack of Neuronetics, Inc. that recently appeared in the literature. In it, he looks at clinical methodology and its implications for the study of therapeutic interventions for chronic fatigue syndrome (CFS). His comments might just as easily apply to PBS/IC, and are worth noting.
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Symptom Severity of PBS/IC Difficult To Predict Based On Medical History And Demographics
Tuesday, 20 June 2006
BERKELEY, CA (UroToday.com) - The association, if any, between medical or demographic characteristics and symptom severity in chronic prostatitis/ chronic pelvic pain syndrome (CP/CPPS) and PBS/IC patients has not been well studied. Clemens and colleagues from Northwestern University reviewed their patient database covering 1999 to 2002 to identify patients diagnosed with CP/CPPS and IC. Questionnaires were mailed to these patients, and nonresponders were followed up 6 months later. The questionnaires asked for information on demographics, medical history, and smoking and alcohol intake. A standardized mental health questionnaire was administered, and females were sent the O'Leary Sant Symptom and Problem Indexes as well as the AUA Symptom Index. Men were sent the NIH chronic prostatitis symptom index.
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European Society For the Study Of Interstitial Cystitis (ESSIC) Reports Latest Efforts In Formulating Rationale And User-Friendly Definitions Of PBS/IC And “Confusable” Disorders
Monday, 19 June 2006
BERKELEY, CA (UroToday.com) - The results of the latest meeting of ESSIC in Baden, Germany have been published, and provide a very well thought-out and organized conception of painful bladder syndrome, interstitial cystitis, the components of its diagnosis, and definitions of other disorders that can result in confusion in diagnosis. Joop van de Merwe and Jorgen Nordling have put together a cogent, concise summary of the meeting which details European views and will be influential around the world.
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The n-of-1 Trial: An Opportunity For Complementary And Alternative Medicine Evaluation That May Be Applicable To The Study Of PBS/IC Treatments
Tuesday, 13 June 2006
BERKELEY, CA (UroToday.com) - This interesting article was brought to my attention by Dr. Tony Buffington at Ohio State. It is an extremely interesting rationale for the use of n-of-1 randomized trials, particularly for complementary and alternative medicine evaluation in the treatment of chronic, difficult to treat disorders. PBS/IC would seem to come under this rubric.
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Relationship Between Painful Bladder Syndrome And Idiopathic Orthostatic Cyclic Edema Is Postulated
Monday, 12 June 2006
BERKELEY, CA (UroToday.com) - Described over 50 years ago, the condition known as idiopathic orthostatic cyclic edema is associated with nocturia, chronic refractory urticaria and failure to lose weight. It is thought that a defect in the response from the sympathetic nerve endings allows water to leak from intravascular to extravascular spaces in the orthostatic position. Sympathetic amines are believed effective in treating this condition by means of correcting this defect. A water load test is used to diagnose the condition once other causes of inability to clear a free water load have been excluded, e.g., hypothyroidism, congestive heart failure, cirrhosis, or nephrosis. Failure to excrete more than 55% of an ingested water load of 1500cc in 30 minutes over a four hour period is thought to be abnormal, though modifying the definition to 75% increases the population considered to have this diagnosis significantly. The test is repeated with the patient supine and standing.
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AUA 2006 - Infections/Inflammation of the GU Tract: Interstitial Cystitis
Wednesday, 24 May 2006
The poster session on interstitial cystitis (IC) included a number of clinical and basic science presentations. Ken Peters and Philip Hanno moderated the session, which included some lively discussions. Some of the highlights follow.
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References
Wednesday, 17 May 2006
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Do Symptoms Correlate With Cystoscopic Findings In Newly Diagnosed PBS/IC?
Friday, 21 April 2006
BERKELEY, CA (UroToday.com) - In patients with untreated and newly diagnosed PBS/IC, can one find a correlation between symptoms and cystoscopic findings?
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Saccharide Complexes Improve Binding Of Pentosanpolysulfate An Heparin To Bladder Epithelium
Monday, 17 April 2006
BERKELEY, CA (UroToday.com) - Anionic glycosaminoglycans including pentosanpolysulphate (PPS) and heparin show weak or no staining of the bladder epithelium and thus do not bind to human or rabbit bladder epithelium in any appreciable amounts.
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IC Average Cost In First Year After Diagnosis $3000 Or More
Tuesday, 11 April 2006
BERKELEY, CA (UroToday.com) - Wu and colleagues studied data for patients under age 65 with at least one diagnosis of IC from a de-identified administrative database of 2 million beneficiaries that included medical, drug and disability claims for 1999-2002.
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DMSO Still Worthwhile Treatment For PBS/IC
Monday, 03 April 2006
BERKELEY, CA (UroToday.com) - Ever since Bruce Stewart popularized the use of intravesical dimethylsulfoxide (DMSO) for the treatment of PBS/IC 40 years ago, it has been a valuable tool for healthcare providers treating this frustrating condition.
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