Botulinum toxin (BTX) is a neurotoxin produced by bacterium clostridium. It is the most poisonous naturally occurring substance known to mankind. The neurotoxin binds to the peripheral cholinergic terminals and inhibits acetylcholine release at that junction leading to flaccid paralysis. This process appears to offer an attractive therapeutic option, filling the void between anticholinergics and surgery in cases of neurogenic and idiopathic detrusor overactivity, detrusor sphincter dyssynergia (DSD), interstitial cystitis and pelvic pain. This article reviews the application of Botulinum toxin A in these conditions.

Written by
Sinha D, Karri K, Arunkalaivanan AS.

Reference
Eur J Obstet Gynecol Reprod Biol. 2007 Jul;133(1):4-11. Epub 2007 Feb 2
doi:10.1016/j.ejogrb.2006.12.014

PubMed Abstract
PMID:17275980

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