Division of Epidemiology and Biostatistics, School of Public Health, University of Illinois at Chicago, Chicago, Ill., USA

This study quantifies the risk of second primary tumors following a diagnosis of meningioma. 12,012 meningiomas and 926 second primary cancers were identified (ICD7, path code 461) between1958 and 1997 using Swedish Cancer Registry data. Standardized incidence ratios (SIRs) and exact 95% confidence intervals (CIs) were calculated. An elevated risk of any second primary cancer diagnosis (SIR = 1.2, 95% CI = 1.1-1.3) was observed. Elevated and statistically significant SIRs were observed for renal cancer (SIR = 1.6), melanoma (SIR = 1.7), thyroid cancer (SIR = 2.6) and brain tumors (SIR = 2.6). A consistent pattern of risk over time supports the evaluation of common risk factor profiles for renal, melanoma and thyroid cancers. Radiation exposures increase the risk of these rare tumors, so quantifying the cumulative and shared effects of environmental and treatment exposures is of further interest. Copyright (c) 2007 S. Karger AG, Basel.

Written by
Davis F, Tavelin B, Grutsch J, Malmer B.

Reference
Neuroepidemiology. 2007 Oct 16;29(1-2):101-106 [Epub ahead of print]
doi:10.1159/000109823

PubMed Abstract
PMID:17940341

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