European Urology - Ability of Cyclohexenonic Long-Chain Fatty Alcohol to Reverse Diabetes-Induced Cystopathy in the Rat
Monday, 26 February 2007
Volume 51, Issue 2, Pages 479-488 (February 2007)
Abstract -
Objectives:
We investigated the ability of 3-(15 hydroxypentadecyl)-2,4,4-trimethyl-2-cyclohexen 1-one (N-hexacosanol), a neurotrophic substance, to reverse diabetes-induced cystopathy in the rat.
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European Urology - Current Status of Minimally Invasive Ablative Techniques in the Treatment of Small Renal Tumours
Wednesday, 21 February 2007
Volume 51, Issue 2, Pages 328-336 (February 2007) 1. Introduction: Due to widespread use of modern imaging techniques such as cross-sectional computed tomography (CT) and magnetic resonance imaging (MRI), the detection rate of renal neoplasms is continually increasing. Depending on the clinical context, the incidental finding of a small renal mass <4cm in asymptomatic patients may pose a therapeutic dilemma [1].
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Serum Immunosuppressive Acidic Protein Doubling Time as a Prognostic Factor for Recurrent Renal Cell Carcinoma After Nephrectomy
Thursday, 15 February 2007
BERKELEY, CA (UroToday.com) - Serum Immunosuppressive Acidic Protein (IAP) levels have been shown to be prognostic in patients with metastatic renal cell carcinoma (RCC).
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Impact of Positive Surgical Margins in Patients Undergoing Partial Nephrectomy for Renal Cortical Tumors
Wednesday, 14 February 2007
BERKELEY, CA (UroToday.com) - There have been numerous studies examining the importance of margins in patients undergoing partial nephrectomy for a localized renal mass.
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Computed Tomography-Guided, Resistance-Based, Percutaneous Radiofrequency Ablation of Renal Malignancies Under Conscious Sedation at Two Years of Follow-Up
Wednesday, 14 February 2007
BERKELEY, CA (UroToday.com) - Energy ablation techniques such as radiofrequency ablation (RFA) and cryoablation are gaining increasing acceptance as alternatives to surgical intervention for patients with small renal masses, particularly in those patients who are less than optimal surgical candidates.
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PET Scans for Decision-Making in Metastatic Renal Cell Carcinoma: A Single-Institution Evaluation
Wednesday, 14 February 2007
BERKELEY, CA (UroToday.com) - While PET scans with flourodeoxyglucose have been embraced as a staging tool in a wide variety of oncologic subspecialties, the role of PET scanning in directing the therapy of patients with metastatic renal cell carcinoma (mRCC) remains unclear.
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Radical Nephrectomy: Too Radical for Small Renal Masses
Tuesday, 13 February 2007
BERKELEY, CA (UroToday.com) - There remains several options for the management of an incidental mass in the setting of a normal contralateral kidney.
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Prognostic Factors Associated with Long-Term Survival in Previously Untreated Metastatic Renal Cell Carcinoma
Monday, 12 February 2007
BERKELEY, CA (UroToday.com) - Patients with metastatic renal cell carcinoma (mRCC) overall have a poor prognosis, with median survival in the range of one year.
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Significance of Macroscopic Tumor Necrosis as a Prognostic Indicator for Renal Cell Carcinoma
Monday, 12 February 2007
BERKELEY, CA (UroToday.com) - The observation that renal cell carcinoma (RCC) tumors can develop areas of necrosis that are apparent on radiographic, gross, and microscopic examination is not a new finding.
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p21 is a Prognostic Marker for Renal Cell Carcinoma: Implications for Novel Therapeutic Approaches
Monday, 12 February 2007
BERKELEY, CA (UroToday.com) - The identification and validation of molecular markers of prognosis are the future for renal cell carcinoma (RCC).
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√ Sorafenib in Advanced Clear-Cell Renal-Cell Carcinoma
Thursday, 08 February 2007
√ Editor's Pick: BERKELEY, CA (UroToday.com) - In the January issue of The New England Journal of Medicine, Escudier and colleagues for the TARGET Study Group report the results of a Phase III trial designed to evaluate the efficacy of sorafenib in metastatic renal cancer.
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√ Sunitinib versus Interferon Alfa in Metastatic Renal-Cell Carcinoma
Thursday, 08 February 2007
√ Editor's Pick: BERKELEY, CA (UroToday.com) - In this multicenter trial published in the January 11th issue of The New England Journal of Medicine,
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Diagnosis of Renal Tumors on Needle Biopsy Specimens by Histological and Molecular Analysis
Thursday, 08 February 2007
BERKELEY, CA (UroToday.com) - Preoperative renal mass biopsy is rarely indicated in the management of renal neoplasms as the result of the biopsy rarely changes the treatment recommendation to surgically excise the tumor.
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Hypothyroidism after Sunitinib Treatment for Patients with Gastrointestinal Stromal Tumors
Wednesday, 07 February 2007
BERKELEY, CA (UroToday.com) - Sunitinib is an anti-angiogenic targeted therapy approved by the FDA this year for the treatment of both gastrointestinal stromal tumor (GIST) as well as metastatic renal cell carcinoma.
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Ureteric Embolization: An Alternative Treatment Strategy for Urinary Fistulae Complicating Advanced Pelvic Malignancy
Wednesday, 07 February 2007
BERKELEY, CA (UroToday.com) - Lower urinary tract fistulae and urinary incontinence occasionally complicate advanced pelvic malignancy or its treatment.
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Progression of Renal Tumors after Laparoscopic Radiofrequency Ablation
Tuesday, 06 February 2007
BERKELEY, CA (UroToday.com) - Energy ablative strategies such as radiofrequency ablation (RFA) are gaining increasing acceptance as viable minimally invasive alternatives to open and laparoscopic surgeries for small renal masses.
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A Prospective Randomized EORTC Intergroup Phase 3 Study Comparing the Complications of Elective Nephron-Sparing Surgery and Radical Nephrectomy for Low-Stage Renal Cell Carcinoma
Tuesday, 06 February 2007
BERKELEY, CA (UroToday.com) - Recent studies have suggested that nephron sparing approaches in the treatment of small renal masses is woefully underutilized globally.
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Strong Significant Correlation Between MMP-9 and Systemic Symptoms in Patients with Localized Renal Cell Carcinoma
Tuesday, 06 February 2007
BERKELEY, CA (UroToday.com) - With modern imaging techniques most localized renal cell carcinomas (RCC) are detected as incidental findings during the course of evaluation of unrelated or non-specific complaints.
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European Urology - Minimally Invasive Nephron-Sparing Surgery (MINSS) for Renal Tumours: Part I: Laparoscopic Partial Nephrectomy
Tuesday, 06 February 2007
Volume 51, Issue 2, Pages 337-347 (February 2007) Abstract -Objectives: To review the evolution and current status of extirpative methods (laparoscopic partial nephrectomy [LPN]) of minimally invasive nephron-sparing surgery (MINSS) for renal tumors.
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European Urology - Minimally Invasive Nephron-Sparing Surgery (MINSS) for Renal Tumours: Part II: Probe Ablative Therapy
Tuesday, 06 February 2007
Volume 51, Issue 2, Pages 348-357 (February 2007) Abstract - Objectives: To review the evolution and current status of probe ablative methods of minimally invasive nephron-sparing surgery (MINSS) for renal tumours.
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European Urology - Nephron-Sparing Surgery for Renal Tumours: Acceleration and Facilitation of the Laparoscopic Technique
Tuesday, 06 February 2007
Volume 51, Issue 2, Pages 358-365 (February 2007) Abstract - Objective: Present our surgical technique for and experience with laparoscopic partial nephrectomy (LPN) for renal tumours during warm ischaemia.
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Percutaneous Computerized Tomography Guided Renal Cryoablation Using Local Anesthesia: Pain Assessment
Monday, 05 February 2007
BERKELEY, CA (UroToday.com) - As the technique of laparoscopic and open cryoablation of renal tumors has been popularized, an increasing number of investigators have continued to raise the bar attempting similar ablations using a percutaneous technique.
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Risk of Renal Insufficiency in African-Americans after Radical Nephrectomy for Kidney Cancer
Monday, 05 February 2007
BERKELEY, CA (UroToday.com) - Recent studies have suggested that nephron sparing surgery is significantly underutilized as a treatment approach, and that radical nephrectomy for renal cell carcinoma (RCC) is associated with a significantly increased risk of renal insufficiency.
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Second (2nd) Primary Malignancies Associated With Renal Cell Carcinoma Histological Subtypes - a review
Friday, 02 February 2007
BERKELEY, CA (UroToday.com) - While several population-based studies have found an association between renal cancer and lymphoma,
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Present Strategies in the Treatment of Metastatic Renal Cell Carcinoma: an Update on Molecular Targeting Agents
Thursday, 01 February 2007
BJUI Mini Reviews - February 2007
Advances in the knowledge of the genetic bases and the key role of angiogenesis have allowed for the rational design of new molecules.
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BJUI Mini Reviews - Present Strategies in the Treatment of Metastatic Renal Cell Carcinoma: An Update on Molecular Targeting Agents
Thursday, 01 February 2007
We discuss the rationale and
the clinical development of these novel
molecular-targeted agents, with special
emphasis on updated information presented
at recent meetings because of the relevance
of the data reported and the potential future
impact in the management of patients with
RCC.
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Laparoscopic Partial Nephrectomy for Incidental Stage PT2 or Worse Tumors
Monday, 29 January 2007
BERKELEY, CA (UroToday.com) - The indications for partial nephrectomy have undergone a significant transformation in the last several years.
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UroToday.com Announces New Endourological Intervention: Left Laparoscopic Partial Nephrectomy
Sunday, 28 January 2007
BERKELEY, CA - UroToday.com announced today the addition of a new surgical video to the Urologic Surgical Interventions Corner.
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Population-Based Study of Renal Cell Carcinoma in Children in Germany, 1980-2005: More Frequently Localized Tumors and Underlying Disorders Compared with Adult Counterparts
Thursday, 25 January 2007
BERKELEY, CA (UroToday.com) - Numerous studies have examined the biology of renal cell carcinoma younger patients, the vast majority of which suggesting that patients, even with locally advanced and metastatic disease, have a good prognosis overall.
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Incidence of Benign Lesions for Clinically Localized Renal Masses Smaller Than 7 cm in Radiological Diameter: Influence of Sex
Wednesday, 24 January 2007
BERKELEY, CA (UroToday.com) - In patients with small renal masses, the likelihood of benign histology in contemporary series has ranged between 15 and 20%.
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Is Laparoscopic Nephrectomy the Preferred Approach in Xanthogranulomatous Pyelonephritis?
Tuesday, 23 January 2007
BERKELEY, CA (UroToday.com) - The limits of laparoscopic renal surgery continue to be explored.
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Pure Laparoscopic Radical Nephrectomy with Level II Vena Caval Thrombectomy
Friday, 19 January 2007
BERKELEY, CA (UroToday.com) - The limits of laparoscopic renal surgery continue to be explored (vide supra).
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European Urology - Nephron-Sparing Surgery: Current Developments and Controversies
Friday, 19 January 2007
Volume 51, Issue 1, Pages 12-14 (January 2007) After the initial perplexity on the long-term oncologic efficacy of open nephron-sparing surgery (NSS), several studies in the past decade have shown that NSS offers equally effective local control and similar 5- and 10-yr disease-specific survival rates compared to radical nephrectomy [1].
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European Urology - Serum Levels of Vascular Endothelial Growth Factor (VEGF) and Endostatin in Renal Cell Carcinoma Patients Compared to a Control Group
Friday, 19 January 2007
Volume 51, Issue 1, Pages 168-174 (January 2007) Abstract - Objectives: Renal cell carcinoma (RCC) is a vascularised neoplasm. The importance of the angiogenic process in its growth and metastatic spreading is widely recognised.
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Unilateral Renal Agenesis and the Congenital Solitary Functioning Kidney: Developmental, Genetic and Clinical Perspectives
Wednesday, 17 January 2007
BJUI Mini Review - January 2007 We review the condition termed ‘unilateral renal agenesis’ (URA), i.e. individuals born with non-ectopic, solitary functioning kidneys (SFKs), with contralateral kidneys which fail to form.
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American Urological Association Names New Director of Guidelines
Wednesday, 03 January 2007
BALTIMORE, January 2007 — The American Urological Association (AUA) has announced that Heddy Hubbard, Ph.D., M.P.H., R.N., F.A.A.N. will be the new Director of Guidelines for the association. Dr. Hubbard joined the AUA on December 28, 2006.
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BJUI Mini Reviews - Unilateral Renal Agenesis and the Congenital Solitary Functioning Kidney: Developmental, Genetic and Clinical Perspectives
Monday, 01 January 2007
This article reviews the condition termed ‘unilateral
renal agenesis’ (URA), i.e. individuals born
with non-ectopic, solitary functioning kidneys
(SFKs), with contralateral kidneys which fail to
form.
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Survival and Prognostic Classification of Patients with Metastatic Renal Cell Carcinoma of Bone
Thursday, 28 December 2006
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The Future of Allogeneic Hematopoietic Stem Cell Transplantation for Metastatic Renal Cell Carcinoma in the Era of Target-Specific Therapy
Wednesday, 27 December 2006
BERKELEY, CA (UroToday.com) - Allogeneic hematopoietic stem cell transplantation (BMT) for metastatic renal cell carcinoma (RCC) was first reported by Childs in 1999. In that report, patients received a conditioning regimen of fludarabine/cyclophosphamide, prior to BMT.
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Phase II Study of Lenalidomide in Patients with Metastatic Renal Cell Carcinoma
Monday, 25 December 2006
BERKELEY, CA (UroToday.com) - The treatment of metastatic renal cell carcinoma (RCC) has undergone a dramatic evolution over the past year, with the introduction of new targeted therapies that have demonstrated improved response rates, delayed time to progression, and improved survival over traditional immunotherapeutic approaches.
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Osteopontin Expression is a Marker of Poor Prognosis in Patients with Clear Cell Renal Cell Carcinoma.
Tuesday, 19 December 2006
BERKELEY, CA (UroToday.com) - Osteopontin (OPN) is a phosphorylated glycoprotein that is secreted into the extracellular matrix by a variety of cell types and has diverse functions which include enhancement of tumorigenesis and tumor progression in a variety of human tumors. Here, Matusan and colleagues examine the expression of OPN in human clear cell renal cell carcinoma (RCC).
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No Evidence of Disease after Radiofrequency Ablation in Delayed Nephrectomy Specimens
Friday, 15 December 2006
BERKELEY, CA (UroToday.com) - One of the obvious limitations of the ablative technologies (radiofrequency ablation (RFA) and cryotherapy) is the reliance on radiographic criteria (lack of enhancement) to define success and effective tumor ablation.
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How Does the Radiographic Size of a Renal Mass Compare with the Pathologic Size?
Wednesday, 13 December 2006
BERKELEY, CA (UroToday.com) - Several reports in the past have suggested that there can be measurable differences between the measured size of renal masses as imaged radiographically, and the size of the renal mass measured by the pathologist on the resected surgical specimen.
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Should Radical Nephrectomy be the Standard of Care for Renal Cortical Tumors 4 cm or Less in Size? Increased Incidence of Chronic Renal Disease after Radical Nephrectomy
Tuesday, 12 December 2006
BERKELEY, CA (UroToday.com) - Since the studies of Robson, radical nephrectomy has remained the gold standard for treatment of renal cortical tumors.
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Advanced Kidney Cancer
Thursday, 07 December 2006
BETHESDA, MD (SUO 7th Annual Meeting - December 1-2, 2006:NIH) - In a session moderated by Dr. Michael Atkins, Beth Israel Deaconess Medical Center, Dr. Brian Rini, Cleveland Clinic spoke about the "Recent Advances with Anti-Angiogenic and Targeted Therapeutics: Bevacizumab, Sorafenib, Sunitinib, AG13736 and CCI-779".
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Kidney Cancer Panel
Thursday, 07 December 2006
BETHESDA, MD (SUO 7th Annual Meeting - December 1-2, 2006:NIH) - In a session moderated by Dr. Arie Belldegrun, UCLA, a distinguished panel discussed 5 cases of renal cell cancer. For a 4cm left renal mass, the group agreed with either open or laparoscopic partial nephrectomy.
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Are Small Renal Tumors Harmless? Analysis of Histopathological Features According to Tumors 4 Cm or Less in Diameter
Wednesday, 06 December 2006
BERKELEY, CA (UroToday.com) - It is generally believed that tumor size correlates with biological aggressiveness in renal cell carcinoma (RCC).
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Significant Discrepancy Between Clinical and Pathologic Staging in Renal Cell Carcinoma
Tuesday, 05 December 2006
BERKELEY, CA (UroToday.com) - The treatment algorithm for renal cancer is largely based on the accuracy and reliability of radiographic imaging.
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Residual and Recurrent Disease Following Renal Energy Ablative Therapy: A Multi-Institutional Study
Monday, 04 December 2006
BERKELEY, CA (UroToday.com) - Even as the use of ablative strategies for renal masses such as radiofrequency ablation (RFA) and cryoablation has continued to expand, no guidelines have been proposed for patient follow-up based on the risk of the recurrence.
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European Urology - Simple Enucleation for the Treatment of PT1a Renal Cell Carcinoma: Our 20-Year Experience
Friday, 01 December 2006
Volume 50, Issue 6, Pages 1263-1271 (December 2006) Abstract - Objectives: To evaluate the safety and efficacy of simple enucleation as a conservative treatment for pT1a RCC, and to report on the incidence of major complications, local recurrence, and progression-free and disease-specific survival rates.
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Renal Cancer 
