BJUI Mini Reviews - Molecular Pathways in Bladder Cancer: Part 2
Tuesday, 01 March 2005
This two-part review describes some of
the molecular pathways in bladder cancer in
the context of self-sufficiency in growth
signals, insensitivity to growth-inhibitory
(antigrowth) signals, evasion of programmed
cell death (apoptosis), limitless replicative
potential, sustained angiogenesis, and tissue
invasion and metastasis, the six ‘hallmarks of
cancer proposed by Hanahan and Weinberg
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BJUI Mini Reviews - Non-Transitional Cell Bladder Carcinomas
Tuesday, 01 March 2005
In the present review we adopted the
classification of bladder tumours given by
Murphy
et al.
[1]:
• Epithelial tumours: squamous cell
carcinoma (SCC), adenocarcinoma and small
cell/neuroendocrine carcinoma.
• Nonepithelial: sarcoma,
lymphoepithelioma-like carcinoma,
phaeochromocytoma, melanoma.
• Secondary tumours.
• Benign tumours.
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Detection of Bladder Cancer Using A Point-of-care Proteomic Assay
Monday, 28 February 2005
BERKELEY, CA (UroToday Inc.) - Although cystoscopy is the gold standard for the diagnosis and surveillance of bladder carcinoma, it is routinely combined with urine cytologic or protein assays to attempt to increase its sensitivity.
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Survival Worse for Elderly Undergoing Cystectomy for Bladder Cancer
Friday, 25 February 2005
NEW YORK (Reuters Health) - Elderly patients who undergo radical cystectomy for transitional cell cancer (TCC) of the bladder have significantly worse overall and disease-free survival rates than their younger peers, according to a report in the February 1st issue of Cancer.
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Authors Present Application of Omentum-wrapped Uretero-ureterocutaneostomy After Palliative Cystectomy
Friday, 18 February 2005
BERKELEY, CA (UroToday Inc.) - Uretro-ureterocutaneostomy (UUC) is the simplest form of incontinent urinary diversion, but it was almost abandoned worldwide when Bricker described the ileal conduit in 1952.
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A Review of Bladder Preservation Data in Treatment of Muscle-Invasive Bladder Cancer
Thursday, 03 February 2005
BERKELEY, CA (UroToday Inc.) - In many parts of the world, in order to avoid cystectomies, combination radiation and chemo-therapies are often employed in patients with muscle-invasive bladder cancer.
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Conservative Therapy Effective in Invasive Bladder Cancer
Thursday, 30 December 2004
NEW YORK (Reuters Health) - For select patients with muscle invasive bladder cancer without distant metastases, conservative organ-sparing therapy with transurethral resection, protracted cisplatin and 5-FU chemotherapy, and hyperfractionated radiotherapy is an option to radical cystectomy, according to Italian researchers.
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Systematic Review Links Hospital or Surgeon Volumes with Outcomes of Urologic Oncology Procedures
Tuesday, 21 December 2004
BERKELEY, CA (UroToday Inc.) - It seems intuitive that higher volume centers or surgeons might obtain better outcomes for complex surgical procedures.
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Bladder Cancer Worsens Outlook in Upper Tract Transitional Cell Carcinoma
Friday, 10 December 2004
NEW YORK (Reuters Health) - Patients with upper tract transitional cell carcinoma (UTTCC) who have a history of bladder transitional cell carcinoma (BTCC) have a poorer prognosis than those who have never had bladder cancer, New York-based researchers report in the December issue of the Journal of Urology.
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Outcomes of Differing Ureteral Reimplantation Techniques Following Radical Cystectomy
Wednesday, 24 November 2004
BERKELEY, CA (UroToday Inc.) - Urinary diversion following radical cystectomy requires ureteral reimplantation. For ileal conduits and low-pressure continent diversions, this is often a refluxing reimplantation.
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Elderly Patients Underrepresented in Trials of New Cancer Drugs
Wednesday, 17 November 2004
NEW YORK (Reuters Health) - New research indicates that cancer patients over 65 years of age are underrepresented in registration trials of new cancer agents.
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Preoperative Somatic Symptoms are Associated With Disease Progression in Patients with Bladder Carcinoma After Cystectomy
Monday, 15 November 2004
BERKELEY, CA (UroToday Inc.) - In renal cell carcinoma, the presence of local tumor symptoms and poor performance status have been validated as independent predictors of outcome and tumor recurrence.
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Studer Pouch Urinary Diversion Results in Excellent Long-Term Voiding Patterns and Upper Urinary Tract Outcomes
Thursday, 11 November 2004
BERKELEY, CA (UroToday Inc.) - Patient survival following radical cystectomy is continuing to improve, thus making the outcomes of the urinary diversion critical to long-term health and well-being.
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Preliminary Comparison of CT Generated Virtual Cystoscopy to Standard Cystoscopy
Monday, 08 November 2004
BERKELEY, CA (UroToday Inc.) - The standard evaluation for hematuria includes an upper tract study in the form of either an intravenous urogram (IVU), CT scan or ultrasound or a combination of these, or a bladder cystoscopy.
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BJUI Mini Reviews - The Role of the Nonsurgical Oncologist in the Management of Advanced Transitional Cell Cancer. Part I: Locally Advanced Disease
Monday, 01 November 2004
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BJUI Mini Reviews - The Role of the Nonsurgical Oncologist in the Management of Advanced Transitional Cell Cancer. Part II: Metastatic Disease
Monday, 01 November 2004
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Bladder Cancer Outcomes are Influenced by Surgical Factors
Thursday, 21 October 2004
BERKELEY, CA (UroToday Inc.) - Radical cystectomy (RC) remains the standard of care for patients with muscle-invasive bladder cancer. The Southwest Oncology Group (SWOG) 8710 trial reported that neoadjuvant chemotherapy improved the survival of patients with muscle-invasive bladder cancer treated by RC.
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Results of Intra-arterial Cisplatin and Radiotherapy for Localized Bladder Cancer
Monday, 18 October 2004
BERKELEY, CA (UroToday Inc.) - Radical cystectomy is the standard of care for patients with muscle invasive bladder cancer in the United States.
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Cisplatin with Radiotherapy Helps Preserve Bladder
Friday, 15 October 2004
NEW YORK (Reuters Health) - In patients undergoing radiotherapy for localized bladder cancer, concurrent intra-arterial administration of cisplatin helps achieve high bladder preservation rates, according to the results of a study reported in the October issue of The Journal of Urology.
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Whole Body MRI Rapidly Scans for Metastases
Thursday, 14 October 2004
NEW YORK (Reuters Health) - The results of whole body magnetic resonance imaging (MRI) compare well with other methods of evaluating metastases and can be done rapidly, German researchers report in the October issue of Radiology.
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Anti-Smoking Groups See Hard Task in Congress
Tuesday, 12 October 2004
WASHINGTON (Reuters) - The passage of a major U.S. tax bill on Monday containing a buyout for tobacco farmers has left a bitter taste among public health groups that had hoped to link the funding to new federal laws regulating cigarettes.
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Bladder Cancer Specific Survival is not Adversely Affected by Socio-economic Deprivation in the U.K
Thursday, 07 October 2004
BERKELEY, CA (UroToday Inc.) - Prognostic variables in bladder cancer outcomes include biologic and non-biologic factors.
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Alcohol Consumption is not a Risk for the Development of Bladder Cancer: Data from the Framingham Heart Study
Wednesday, 29 September 2004
BERKELEY, CA (UroToday Inc.) - Epidemiologic findings that support a role for alcohol consumption in the development of bladder cancer have been inconsistent.
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Nabi Says Vaccine Helped Smokers Quit
Wednesday, 29 September 2004
CHICAGO (Reuters) - Nabi Biopharmaceuticals on Tuesday said its NicVAX nicotine vaccine showed promising results in helping smokers quit smoking in a small clinical trial.
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Dogs Sniff Out Bladder Cancer
Monday, 27 September 2004
LONDON (Reuters Health) - The acute sense of smell that makes dogs useful for detecting illegal substances at airports might also be applied in an oncology setting, researchers reported this week.
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Intravesical Gemcitabine Shows Promise in Intermediate Risk Superficial Bladder Cancer
Thursday, 23 September 2004
BERKELEY, CA (UroToday Inc.) - Intermediate risk transitional cell carcinoma (TCC) of the bladder includes approximately 40% of all superficial bladder cancer patients.
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Alcohol Consumption Does Not Raise Risk of Bladder Cancer
Tuesday, 21 September 2004
NEW YORK (Reuters Health) - New research suggests that alcohol consumption does not increase the risk of bladder cancer.
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Octogenarian Bladder Cancer Patients Undergoing Cystectomy May Have Better Survival Than Their Conservatively Treated Counterparts
Friday, 17 September 2004
BERKELEY, CA (UroToday Inc.) - Cancer patients 80 years or older are at competing risks of treatment related complications and mortality versus their existing co-morbidities.
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BJUI Mini Reviews - Technique and Complications of Transurethral Surgery for Bladder Tumours
Wednesday, 01 September 2004
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Risk of Testicular, Kidney and Bladder Cancer is not Increased With Exposure to Diesel or Gasoline Engine Exhaust
Thursday, 26 August 2004
BERKELEY, CA (UroToday Inc.) - Engine exhaust is potentially carcinogenic to humans. While evidence from animal studies suggests this, epidemiologic studies have provided limited evidence, mainly implicating only lung and bladder cancer.
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Increased Diesel Exhaust Exposure Increases Risk of Ovarian Cancer
Monday, 16 August 2004
NEW YORK (Reuters Health) - The risk of ovarian cancer, but not esophageal or testicular cancers, increases with increased exposure to diesel exhaust, according to a new study in the August 20th issue of the International Journal of Cancer.
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Physical Symptoms Predict Survival Time in Terminal Cancer
Tuesday, 27 July 2004
NEW YORK (Reuters Health) - Physical symptoms that affect health-related quality-of-life (QOL), such as nausea and dyspnea, appear to be associated with shorter survival in terminal cancer patients, researchers report in the July 26th online edition of Cancer.
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M. Smegmatis Engineered to SecreteTNF Shows Early Promise in Bladder Cancer
Wednesday, 07 July 2004
LONDON (Agence de Presse Medicale for Reuters Health) - Recombinant Mycobacterium smegmatis secreting tumour necrosis factor-alpha shows early promise in the treatment of bladder cancer, researchers said on Tuesday.
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Organ Sparing Often Successful in Patients with T1G3 Bladder Cancer
Friday, 02 July 2004
NEW YORK (Reuters Health) - Findings from a new study suggest that an organ-preserving surgical approach can spare the bladder in about half of patients with stage T1, grade 3 (T1G3) bladder cancer.
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BJUI Mini Reviews - Small Cell Carcinoma of the Bladder
Thursday, 01 July 2004
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BJUI Mini Reviews - Superficial Transitional (Ta/T1/CIS) Cell Carcinoma of the Bladder
Thursday, 01 July 2004
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Smoking Cuts 10 Years Off Life
Wednesday, 23 June 2004
LONDON (Agence de Presse Medicale for Reuters Health) - Smokers die ten years younger on average than non-smokers, according to new findings from the British study that first proved smoking causes lung cancer.
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Taiwanese Kidney Transplant Recipients are at High Risk for Urinary Tract Cancer
Friday, 18 June 2004
NEW YORK (Reuters Health) - Kidney transplant recipients in Taiwan are at particularly high risk for transitional cell carcinoma of the urinary tract, according to a study in the June issue of the American Journal of Kidney Diseases.
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Quality of Life for Cancer Patients May Be All in the Genes
Thursday, 10 June 2004
NEW ORLEANS (Reuters Health) - The results of a new study provide preliminary evidence of a "potentially strong and specific" relationship between the genetic makeup of cancer patients and their quality of life (QOL) during cancer treatment.
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Effect of Prophylactic Treatment with Intravesical Epirubicin on Recurrence of Superficial Bladder Cancer ? A Dose Escalation Trial
Monday, 07 June 2004
BERKELEY, CA (UroToday Inc.) - Superficial bladder cancer accounts for 60-70% of all bladder cancer cases in Japan, and almost all of those patients are treated by transurethral resection of the bladder (TUR-BT).
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Long-term Results of a Phase II Study of Synchronous Chemoradiotherapy in Advanced Muscle Invasion Bladder Cancer
Tuesday, 01 June 2004
BERKELEY, CA (UroToday Inc.) - Radical radiotherapy is commonly used as an alternative to surgery, especially in the UK.
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MBD2 May Curb Bladder Cancer Risk
Tuesday, 01 June 2004
NEW YORK (Reuters Health) - MBD2, a methyl-CpG-binding domain 2 protein, may protect against bladder carcinoma, according to a report in the May 1st issue of Cancer.
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Intravesical Bacille Calmette-Guerin Versus Mitomycin C in Superficial Bladder Cancer: Formal Meta-Analysis of Comparative Studies on Tumor Progression
Tuesday, 18 May 2004
BERKELEY, CA (UroToday Inc.) - The primary treatment of bladder cancer is transurethral resection of the bladder tumor, but up to 70% of superficial tumors recur.
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Cancer Trial Participants Rarely Told of Results
Wednesday, 21 April 2004
NEW YORK (Reuters Health) - Cancer patients who participate in clinical trials are often left in the dark about the results of the studies, according to a new report.
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Biopsy of the Red Patch at Cystoscopy: Is It Worthwhile?
Monday, 19 April 2004
Cystoscopy is a commonly performed office-based urological procedure. It is principally carried out for diagnosis and follow-up of transitional cell carcinoma of the bladder, as well as for investigation of hematuria and lower urinary tract symptoms.
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Combination of Tumor Markers Best Predicts Bladder Cancer Outcome
Friday, 09 April 2004
NEW YORK (Reuters Health) - Results of a study indicate that altered expression of four key cell cycle regulators - p53, p21, pRB, and p16 - predict clinical outcome after cystectomy for transitional cell carcinoma (TCC) of the bladder cancer.
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Rhabdomyosarcoma of the Bladder, Prostate or Vagina: The Role of Surgery
Thursday, 25 March 2004
BERKELEY, CA (UroToday Inc.) - Of all reported rhabdomyosarcoma (RMS), 13-20% arises within the genitourinary tract, most commonly in the bladder, prostate, vagina, uterus or paratesticular tissue.
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Laparoscopic Bladder Diverticulectomy is a Promising Alternative to Open Surgery
Thursday, 25 March 2004
Bladder diverticula result from the herniation of the bladder mucosa through the detrussor muscle. This most often occurs near the ureteral hiatus and as a result of bladder outlet obstruction.
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New Tumor Classification Scheme Unlinks Tumor Type From Tumor Site
Wednesday, 24 March 2004
NEW YORK (Reuters Health) - A radically different new system for classification of tumors has been set forth by a National Cancer Institute official.
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Aprepitant Regimen Sustains Antiemetic Effect Over Multiple Chemotherapy Cycles
Tuesday, 23 March 2004
NEW YORK (Reuters Health) - The addition of the drug aprepitant to other antiemetic therapy is associated with less nausea and vomiting during an initial cycle of chemotherapy, and the response is maintained well during subsequent cycles, investigators report.
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Bladder Cancer 
