Mayo Clinic Validation of the D'Amico Risk Group Classification for Predicting Survival Following Radical Prostatectomy
Thursday, 15 May 2008
BERKELEY, CA (UroToday.com) - Dr. Boorjian and colleagues from the Mayo Clinic validated the D’Amico risk classification of predicting survival following radical prostatectomy (RP) using their single institution cohort of 7,591 patients.
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Comparison of Blade Temperature Dynamics after Activation of Harmonic Ace Scalpel and the Ultracision Harmonic Scalpel LCS-K5
Thursday, 01 May 2008
BERKELEY, CA (UroToday.com) - Not all harmonic shears are created equal - surgeon beware.
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SUFU 2008 Winter Meeting - Society for Urodynamics and Female Urology Holds International Meeting to Assess Areas of Consensus and Disagreement Regarding Interstitial Cystitis / Bladder Pain Syndrome
Saturday, 26 April 2008
BERKELEY, CA (UroToday.com) - Over the last 6 years there have been ongoing efforts around the world to standardize nomenclature, definition, and evaluation of interstitial cystitis/bladder pain syndrome/painful bladder syndrome.
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Association of Preterm Birth with Long-Term Survival, Reproduction, and Next-Generation Preterm Birth
Friday, 25 April 2008
BERKELEY, CA (UroToday.com) - Preterm birth (birth < 37 weeks) is a major cause of infant morbidity and mortality.
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Trends in Gleason Score: Concordance Between Biopsy and Prostatectomy over 15 Years
Thursday, 27 March 2008
BERKELEY, CA (UroToday.com) - Gleason score remains one of the strongest prognostic predictors of treatment outcome in patients with prostate cancer (CaP).
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Single-Port Laparoscopic Surgery in Urology: Initial Experience
Thursday, 13 March 2008
BERKELEY, CA (UroToday.com) - The hottest area of minimally invasive surgery is now that of NOTES (natural orifice transluminal endoscopic surgery) and SPA (single port access).
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Cumulative Association of Five Genetic Variants with Prostate Cancer
Thursday, 21 February 2008
BERKELEY, CA (UroToday.com) - In addition to age, race, and a positive family history it is now known that variants in chromosomal regions are associated with a risk of prostate cancer (CaP).
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Absence of Cancer Diagnosis and Treatment in Elderly Medicaid-Insured Nursing Home Residents
Thursday, 14 February 2008
BERKELEY, CA (UroToday.com) - A study in the January 2008 issue of the Journal of the National Cancer Institute suggests that Medicaid patients in nursing home care receive limited cancer services.
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Renal Function Outcomes in Patients Treated with Renal Masses Smaller than 4 cm by Ablative and Extirpative Techniques
Thursday, 14 February 2008
BERKELEY, CA (UroToday.com) - This is an extremely important report of the importance of preserving as much normal functioning renal tissue as possible when treating patients with renal tumor disease.
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Docetaxel Plus Prednisone or Mitoxantrone Plus Prednisone for Advanced Prostate Cancer: Updated Survival in the TAX 327 Study
Thursday, 17 January 2008
BERKELEY, CA (UroToday.com) - The TAX 327 study was reported in 2004 and evaluated patients with hormone-refractory prostate cancer (HRPC) in three treatment arms; docetaxel 75mg/m2 every 3 weeks (D3P), docetaxel 30mg/ m2 weekly (D1P), or mitoxantrone 12 m2 every 3 weeks (MP), each with prednisone 5mg twice daily.
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A Phase II Clinical Trial of Sorafenib in Androgen-Independent Prostate Cancer
Thursday, 17 January 2008
BERKELEY, CA (UroToday.com) - In the January 1, 2008 issue of Clinical Cancer Research, Dr. Dahut and colleagues report a Phase II trial of Sorafenib in androgen-independent prostate cancer (AICaP).
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Obesity-Related Plasma Hemodilution and PSA Concentration among Men with Prostate Cancer
Thursday, 10 January 2008
BERKELEY, CA (UroToday.com) -The important association that increased circulating plasma volumes in obese men may hemodilute PSA and result in lower levels is reported in the November 21, 2007 issue of the Journal of the American Medical Association by Dr. Banez and associates.
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Obesity and Mortality in Men with Locally Advanced Prostate Cancer
Thursday, 10 January 2008
BERKELEY, CA (UroToday.com) - An analysis of RTOG 85-31 patients suggests that increased body mass index (BMI) is associated with increased prostate cancer specific mortality (PCSM). The report appears in the online version of Cancer and is authored by Dr. Efstathiou and collaborators.
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Androgen Deprivation Therapy for Localized Prostate Cancer and the Risk of Cardiovascular Mortality
Thursday, 10 January 2008
BERKELEY, CA (UroToday.com) - Androgen deprivation therapy (ADT) is associated with metabolic syndrome, which includes the development of type II diabetes mellitus and coronary artery disease.
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The Phoenix Definition of Biochemical Failure Predicts for Overall Survival in Patients with Prostate Cancer
Thursday, 03 January 2008
BERKELEY, CA (UroToday.com) - The Phoenix definition of prostate cancer biochemical failure (BF) following radiotherapy (XRT) is a more robust determinant of patient outcome compared with the ASTRO definition according to a report in the online version of Cancer, by Dr. Abramowitz and colleagues.
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Percutaneous Core Biopsy for Renal Masses: Indications, Accuracy and Results
Friday, 09 November 2007
BERKELEY, CA (UroToday.com) - Heads-up – paradigm shift on the horizon!
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Laparoscopic Radical Cystectomy for Cancer: Oncological Outcomes at up to 5 years
Friday, 28 September 2007
BERKELEY, CA (UroToday.com) - This article published in the British
Journal of Urology International by Georges-Pascal and Gill detail the
oncologic findings and short-term recovery from laparoscopic radical
cystectomy for clinically organ confined bladder cancer. The authors
evaluated 37 patients who underwent laparoscopic radical cystectomy
from 1999 to 2005.
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Gonadal Function in Males after Chemotherapy for Early-Stage Hodgkin's Lymphoma Treated in Four Subsequent Trials by the European Organisation for Research and Treatment of Cancer: EORTC Lymphoma Group and the Groupe d'Étude des Lymphomes de l'Adulte
Wednesday, 25 July 2007
BERKELEY, CA (UroToday.com) - Few studies have evaluated the impact of contemporary chemotherapy on fertility in young men treated for early stage lymphoma.
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EPCA-2: A Highly Specific Serum Marker for Prostate Cancer
Monday, 16 July 2007
BERKELEY, CA (UroToday.com) - The steady decrease in prostate cancer mortality is indirect evidence that prostate cancer early detection using serum PSA and the digital rectal examination saves lives.
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Under Diagnosis and Over Diagnosis of Prostate Cancer: Under Diagnosis and Over Diagnosis of Prostate Cancer in a Screening Population with Serum PSA 2 to 10 ng/ml
Tuesday, 03 July 2007
BERKELEY, CA (UroToday.com) - According to reports from the US and Europe it is more common that prostate cancer (CaP) is under diagnosed than over diagnosed. Both studies appear in the July 2007 issue of the Journal of Urology.
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The Current State of Miniature in Vivo Laparoscopic Robotics
Thursday, 28 June 2007
BERKELEY, CA (UroToday.com) - Firstly, I would like to say kudos to Vip Patel on the publication of Volume 1, number 1 of the new Journal of Robotic Surgery.
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Influence of Androgen Suppression Therapy for Prostate Cancer on the Frequency and Timing of Fatal Myocardial Infarctions
Monday, 25 June 2007
BERKELEY, CA (UroToday.com) - Recent studies have suggested that patients treated with androgen deprivation therapy for more than 12 months may exhibit nearly a 50% risk of developing the metabolic syndrome.
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Temsirolimus, Interferon Alfa, or Both for Advanced Renal-Cell Carcinoma
Tuesday, 19 June 2007
BERKELEY, CA (UroToday.com) - Temsirolimus is a specific inhibitor of mTOR kinase a key component of intracellular signaling involved in cell proliferation.
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Remote Telepresence Surgery: The Canadian Experience
Thursday, 07 June 2007
BERKELEY, CA (UroToday.com) - This important report from Canada presents 22 telerobotic general surgery laparoscopy cases performed by two surgeons over a distance of 400 kilometers; from a teaching hospital in Hamilton, Ontario to a community hospital in rural Northern Ontario.
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Burch Colposuspension versus Fascial Sling to Reduce Urinary Stress Incontinence
Wednesday, 30 May 2007
BERKELEY, CA (UroToday.com) - Significant variability exists in the selection of anti-incontinence procedures by both urologists and gynecologists. While pubovaginal sling procedures have gained significant popularity in the last 10 years, few randomized trials have compared their efficacy and safety to traditional retropubic procedures.
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Matrix Metalloproteinase Polymorphisms Are Associated with Bladder Cancer Invasiveness
Wednesday, 09 May 2007
BERKELEY, CA (UroToday.com) - While early cystectomy is indicated in select patients with polychronotropic stage Ta, T1, and CIS bladder cancer, the standard of care to prevent tumor progression for these patients continues to be intravesical BCG.
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Age at Surgery for Undescended Testis and Risk of Testicular Cancer
Tuesday, 08 May 2007
BERKELEY, CA (UroToday.com) - While all urologists would agree that an undescended testis found in a school-age boy should be treated with an inguinal orchidopexy, whether the procedure results in a decrease in testicular cancer risk remains unclear.
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Complications of 2,775 Urological Laparoscopic Procedures: 1993 to 2005
Monday, 26 March 2007
BERKELEY, CA (UroToday.com) - In this very large, long-term, retrospective study in which nearly 85% of the laparoscopic procedures were nonpelvic (e.g. renal, adrenal, or retroperitoneal), the overall complication rate was 22%: 4.7% (intraoperative) and 17.5% (postoperative); the mortality rate was 0.07%.
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Post-Percutaneous Nephrolithotomy Extensive Hemorrhage: A Study of Risk Factors
Wednesday, 21 March 2007
BERKELEY, CA (UroToday.com) - This is by far the most comprehensive review of bleeding complications after percutaneous nephrolithotomy published to date.
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Effect of Advanced Age on Laparoscopic Urologic Procedures
Wednesday, 21 March 2007
BERKELEY, CA (UroToday.com) - Quite simply, in any laparoscopic procedure there are two factors, the surgeon and the patient.
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Laparoscopic Versus Open Radical Nephrectomy for Xanthogranulomatous Pyelonephritis: Contemporary Outcomes Analysis
Wednesday, 14 March 2007
BERKELEY, CA (UroToday.com) - It was not until 9 years after the initial laparoscopic nephrectomy, that the first report on using this technique for xanthogranulomatous pyelonephritis (XGP) emerged from Washington University.
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Time to an Undetectable Prostate-Specific Antigen (PSA) after Androgen Suppression Therapy for Postoperative or Postradiation PSA Recurrence and Prostate Cancer-Specific Mortality (p NA)
Tuesday, 13 March 2007
BERKELEY, CA (UroToday.com) - Prostate cancer is the most common malignancy in men.
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Weekly Docetaxel and Prednisolone versus Prednisolone Alone in Androgen-Independent Prostate Cancer: A Randomized Phase II Study
Friday, 02 March 2007
BERKELEY, CA (UroToday.com) - In 2004 two large randomized clinical trials demonstrated that docetaxel based chemotherapy improved survival in androgen-independent prostate cancer (AICAP).
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Inhibitory Effect of Snake Venom Toxin from Vipera lebetina turanica on Hormone-Refractory Human Prostate Cancer Cell Growth: Induction of Apoptosis Through Inactivation of Nuclear Factor ΚB
Thursday, 01 March 2007
BERKELEY, CA (UroToday.com) - Snake venom as therapeutic treatment of cancer?
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Double-Blinded Randomized Study of High-Dose Calcitriol Plus Docetaxel Compared With Placebo Plus Docetaxel in Androgen-Independent Prostate Cancer: A Report From the ASCENT Investigators
Wednesday, 28 February 2007
BERKELEY, CA (UroToday.com) - Calcitriol is the natural ligand for the Vitamin D receptor and is known to inhibit prostate cancer (CaP) proliferation, invasiveness, and angiogenesis and to induce apoptosis.
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Relevance of the Prostate-Specific Antigen (PSA) Nanotest Compared to the Classical PSA Test in the Organized Mass Screening of Prostate Cancer
Friday, 23 February 2007
BERKELEY, CA (UroToday.com) - A simple finger prick of blood collected on blotting paper and mailed into a lab had accurate correlation with the standard PSA assay in men with PSA levels less than 5ng/ml, according to an online report in the BJU International by Dr. Azzouzi and associates in France.
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The Prognostic Role of a Gene Signature from Tumorigenic Breast-Cancer Cells
Thursday, 22 February 2007
BERKELEY, CA (UroToday.com) - A gene expression profile in human breast tumors correlates with metastasis-free survival and overall survival for several tumor types to include prostate cancer (CaP), according to a report in the January 18, 2007 edition of the New England Journal of Medicine.
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Brief Report: Prepubertal Gynecomastia Linked to Lavender and Tea Tree Oils
Friday, 16 February 2007
BERKELEY, CA (UroToday.com) - Prepubertal gynecomastia is uncommon and idiopathic in over 90% of cases.
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Variation in the Definition of Biochemical Recurrence in Patients Treated for Localized Prostate Cancer: The AUA Prostate Guidelines for Localized CaP Update Panel Report & Recommendations for a Standard in the Reporting of Surgical Outcomes
Thursday, 15 February 2007
BERKELEY, CA (UroToday.com) - One of the problems with prostate cancer outcomes studies is the lack of standardization in the definition of "treatment failure".
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Sorafenib in Advanced Clear-Cell Renal-Cell Carcinoma
Thursday, 08 February 2007
BERKELEY, CA (UroToday.com) - In the January issue of The New England Journal of Medicine, Escudier and colleagues for the TARGET Study Group report the results of a Phase III trial designed to evaluate the efficacy of sorafenib in metastatic renal cancer.
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Sunitinib versus Interferon Alfa in Metastatic Renal-Cell Carcinoma
Thursday, 08 February 2007
BERKELEY, CA (UroToday.com) - In this multicenter trial published in the January 11th issue of The New England Journal of Medicine,
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Survival Associated with Treatment vs. Observation of Localized Prostate Cancer in Elderly Men
Wednesday, 31 January 2007
BERKELEY, CA (UroToday.com) - Without randomized trials of treatment vs. observation in elderly men with prostate cancer (CaP), it has been the assumption that these men will succumb to other causes.
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Short-Term Impact of a Laparoscopic “Mini-Residency” Experience on Postgraduate Urologists’ Practice Patterns
Thursday, 18 January 2007
BERKELEY, CA (UroToday.com) - "A difference to be a difference must make a difference" was attributed to Gertrude Stein. The goal of all teaching and training is to develop this "higher" level of knowledge or skill, but not all efforts to instruct result in an effective difference.
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Adjuvant Radiotherapy for Pathologically Advanced Prostate Cancer: A Randomized Clinical Trial
Tuesday, 19 December 2006
BERKELEY, CA (UroToday.com) - Despite the number of radical prostatectomies performed around the world, the role of adjuvant radiotherapy in the management of patients with locally advanced prostate cancer remains controversial.
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Phase II Trial of Interferon in Combination with Thalidomide for Metastatic Renal Cell Carcinoma
Monday, 20 November 2006
BERKELEY, CA (UroToday.com) - Both thalidomide and -interferon (IFN) have been utilized as monotherapy in the treatment of patients with metastatic renal cell carcinoma (RCC), each with modest evidence of activity and acceptable toxicity profiles.
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Obesity, Diabetes, and Risk of Prostate Cancer: Results from the Prostate Cancer Prevention Trial
Wednesday, 15 November 2006
BERKELEY, CA (UroToday.com) - The association between obesity and prostate cancer risk remains controversial.
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PSA Velocity Greater Than 2 NG/ML the Year Before Diagnosis Independently Predicts Prostate Cancer Mortality in Men Treated with Radical Prostatectomy or Radiotherapy
Tuesday, 14 November 2006
BERKELEY, CA (UroToday.com) - In the past, prostate cancer risk stratification before definitive treatment had been largely based on preoperative serum PSA, Gleason score, clinical stage, and the percent of positive biopsies on biopsy. Recently, PSA velocity before diagnosis has been increasingly implicated in prostate cancer prognosis.
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Fatty Fish Consumption Associated with Decreased Risk of Renal Cancer in Women
Wednesday, 18 October 2006
BERKELEY, CA (UroToday.com) - The consumption of fatty fish such as salmon, herring, and mackerel has been associated with a reduction in the incidence of prostate cancer. This has not been previously studied in other urological malignancies.
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Model Predicts Survival Time in Patients with Recurrent Renal Cell Carcinoma
Tuesday, 03 October 2006
BERKELEY, CA (UroToday.com) - In the July 1, 2006 issue of the Journal of Clinical Oncology, Dr. Eggener and associates at Memorial Sloan Kettering Cancer Center describe a model that stratifies patients with a recurrence of renal cell carcinoma (RCCA) by risk factors to predict survival time.
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The Effects of the Dual 5 Alpha -Reductase Inhibitor Dutasteride on Localized Prostate Cancer - Results From a 4-Month Pre-Radical Prostatectomy Study
Monday, 02 October 2006
BERKELEY, CA (UroToday.com) - Finasteride, a 5- reductase inhibitor reduced the prevalence of prostate cancer (CaP) in the Prostate Cancer Prevention Trial.
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