BERKELEY, CA (UroToday.com) - The investigation originally involved CDC91L1(PIG-U) expression at both the mRNA and protein levels and the clinical and prognostic significance of CDC91L1 expression in bladder cancer. This would help clarify the therapeutic potential of CDC91L1 in bladder cancer; therefore helping to develop feasible ways using this target therapeutically or predicatively in future clinical practices and basic researches of bladder cancer. By molecular experimental methods including RT-PCR, Real-time quantitative PCR, and immunohistochemistry, and tested by powerful scientific statistics, we found CDC91L1(PIG-U) was up-regulated at both the mRNA and protein levels. CDC91L1 protein may be a potential tumor biomarker for prediction of bladder cancer and is a promising therapeutic target. This is one of the novel and salient findings of GPI transamidase subunits in cancer research. It’s also important and interesting for cancer researchers to make more efforts in the treatment of bladder cancer through GPI transamidase subunits.

Written by
Yijun Shen M.D. - Department of Urology - Cancer Hospital Fudan University - Shanghai, China, as part of Beyond the Abstract on UroToday.com. This initiative offers a method of publishing for the professional urology community. Authors are given an opportunity to expand on the circumstances, limitations etc... of their research by referencing the published abstract.

Overexpression of CDC91L1 (PIG-U) in Bladder Urothelial Cell Carcinoma: Correlation with Clinical Variables and Prognostic Significance - Abstract

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