Beyond the Abstract - Mayo Clinic Validation of the D'Amico Risk Group Classification for Predicting Survival Following Radical Prostatectomy
Tuesday, 11 March 2008
BERKELEY, CA (UroToday.com) - The study here externally validates the ability of the D’Amico risk group classification to predict clinical progression as well as cancer-specific and overall survival after RRP using the largest series of surgical patients (7,591) evaluated using this model to date.
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Beyond the Abstract - Sensitivity of Normal, Paramalignant, and Malignant Human Urothelial Cells to Inhibitors of the Epidermal Growth Factor Receptor Signaling Pathway
Tuesday, 11 March 2008
BERKELEY, CA (UroToday.com) - Starting from a well-established cell culture system of normal human urothelial cells 1,2, the epithelial cells that line the bladder, we used retroviral transduction to generate “designer” cell lines with specific molecular alterations.
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Beyond the Abstract - External Validation of IMP3 Expression as an Independent Prognostic Marker for Metastatic Progression and Death for Patients with Clear Cell Renal Cell Carcinoma
Tuesday, 11 March 2008
BERKELEY, CA (UroToday.com) - This trial was a validation of IMP3 as marker for the aggressiveness of renal cell carcinoma.
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Beyond the Abstract - Combined Exposure to Anti-Androgens Causes Markedly Increased Frequencies of Hypospadias in the Rat
Tuesday, 04 March 2008
BERKELEY, CA (UroToday.com) - The study is a part of a larger study on mixtures of anti-androgens in a rat model.
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Beyond the Abstract - Reliability of the 24-h Sensation-Related Bladder Diary in Women with Urinary Incontinence
Tuesday, 04 March 2008
BERKELEY, CA (UroToday.com) - Our group evaluated a 3-day Sensation Related Bladder Diary (SR-BD) from 246 incontinent women.
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Beyond the Abstract - Guide to Drug Therapy for Lower Urinary Tract Symptoms in Patients
Tuesday, 04 March 2008
BERKELEY, CA (UroToday.com) - Sexuality is an important component of an individual’s sense of well-being and quality of life (QOL).
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Beyond the Abstract- Anatomic Excision of Anterior Prostatic Fat at Radical Prostatectomy: Implications for Pathologic Upstaging
Tuesday, 04 March 2008
BERKELEY, CA (UroToday.com) - It is very exciting when you take an operation that has been around since 1905 and uncover new information that was literally right in front of us all along.
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Beyond the Abstract - Prostate Cancer Volume at Biopsy Predicts Clinically Significant Upgrading
Tuesday, 04 March 2008
BERKELEY, CA UroToday.com - Despite two decades of experience, the clinical evaluation of the prostate cancer patient in the context of PSA screening remains controversial.
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Beyond the Abstract - Dietary Modification in Patients With Prostate Cancer on Active Surveillance: A randomized, Multicentre Feasibility Study
Tuesday, 26 February 2008
BERKELEY, CA (UroToday.com) - To our knowledge, this is the first clinical trial to report the
application of a major, validated, diet-based intervention as a single
form of therapy in active surveillance patients.
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Beyond the Abstract - Female Sexual Dysfunction: A New Urogynaecological Research Field
Tuesday, 26 February 2008
BERKELEY, CA (UroToday.com) - Female sexual dysfunction represents a new and underestimated field in urogynaecological research.
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Beyond the Abstract - Nonsecretory Intestinocystoplasty: A 15-Year Prospective Study of 183 Patients
Tuesday, 26 February 2008
BERKELEY, CA (UroToday.com) - Improving bladder capacity and compliance by surgical methods continues to be challenging specially for children and young adults with long life expectancy.
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Beyond the Abstract - Effects of Phosphodiesterase-5 Inhibitors on Sperm Parameters and Fertilizing Capacity
Tuesday, 26 February 2008
BERKELEY, CA (UroToday.com) - The aim of this review study is to provide some answers concerning the detrimental or beneficial effects of PDE5 inhibitors on sperm parameters, capacitation process and on spermatozoal ability to fertilize the oocytes.
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Beyond the Abstract - Metastatic Adenocarcinoma After Augmentation Gastrocystoplasty
Tuesday, 26 February 2008
BERKELEY, CA (UroToday.com) - The authors believe that this case series highlights a concern that was once theoretical and now appears real: the ideal screening regimen and
the true incidence of malignancy in patients who have undergone bladder
augmentation remain unknown.
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Beyond the Abstract - Calcineurin Inhibitor-Sparing Regimens in Solid Organ Transplantation: Focus on Improving Renal Function and Nephrotoxicity
Tuesday, 19 February 2008
BERKELEY, CA (UroToday.com) - Clinical solid organ transplantation is a great success story, and when permanent failure of the kidney, liver, heart, or lung occurs, replacement by transplant is the preferred treatment option.
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Beyond the Abstract - Uroplakin III-Delta4 Messenger RNA as a Promising Marker to Identify Nonulcerative Interstitial Cystitis
Tuesday, 19 February 2008
BERKELEY, CA (UroToday.com) - Uroplakin III-delta 4, a splice variant of UP III, was isolated by my Japanese colleagues, Dr. T Yoshiki and others, although its protein structure and function still remains unclear.
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Beyond the Abstract - Clinical Significance of Low Level Human Chorionic Gonadotropin in the Management of Testicular Germ Cell Tumor
Tuesday, 19 February 2008
BERKELEY, CA (UroToday.com) - HCG measurement is essential in the management of testicular germ cell tumor(GCT), there are some cases with unexplained continuous low levels of serum
human chorionic gonadotropin (hCG) without clinical evidence of disease (this syndrome called “low-level hCG”).
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Beyond the Abstract - Pharmacology and New Perspectives of Angiotensin II Receptor Blocker in Prostate Cancer Treatment
Tuesday, 12 February 2008
BERKELEY, CA (UroToday.com) - AT1 receptor blockers (ARBs) possessing our experimental demonstrations may offer clinical efficacy in patients with hormone refractory prostate cancer (HRPC).
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Beyond the Abstract - Surgical Treatment of Peyronie's Disease: Choosing the Best Approach to Improve Patient Satisfaction
Tuesday, 12 February 2008
BERKELEY, CA (UroToday.com) - Peyronie's disease, when associated with a severe penile deformity, causes a devastating condition psychologically and physically.
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Beyond the Abstract - Influence of Prostate Size on the Outcome of Holmium Laser Enucleation of the Prostate
Tuesday, 12 February 2008
BERKELEY, CA (UroToday.com) - High-powered holmium lasers are used for ablation, resection and enucleation of the prostate, as this laser has excellent incisional, ablative and haemostatic properties.
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Beyond the Abstract - Donor Insemination and Infertility: What General Urologists Need to Know
Tuesday, 12 February 2008
BERKELEY, CA (UroToday.com) - In recent decades, therapeutic donor insemination (TDI) has become an increasingly obscure form of infertility treatment.
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Beyond the Abstract - Pazopanib, A Potent Orally Administered Small-Molecule Multi-Targeted Tyrosine Kinase Inhibitor for Renal Cell Carcinoma
Tuesday, 12 February 2008
BERKELEY, CA (UroToday.com) - The regulatory approvals of sunitinib malate, sorafenib tosylate and temsirolimus have improved the therapeutic options for many patients with advanced renal cell carcinoma (RCC).
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Beyond the Abstract - Coagulation of a Giant Hemangioma in Glans Penis with Holmium Laser
Tuesday, 05 February 2008
BERKELEY, CA (UroToday.com) - Penile hemangiomas are very uncommon mesenchymal tumors.
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Beyond the Abstract - Efficacy of Artificial Urinary Sphincter Implantation after Failed Bone-Anchored Male Sling for Postprostatectomy Incontinence
Tuesday, 05 February 2008
BERKELEY, CA (UroToday.com) - Bone Anchored Male sling (BAMS) has been popular in the treatment of mild-moderate post-prostatectomy incontinence but no recommendation has been made in the literature after a failed sling surgery.
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Beyond the Abstract - Abnormal Expression of Differentiation Related Proteins and Proteoglycan Core Proteins in the Urothelium of Patients With Interstitial Cystitis
Tuesday, 29 January 2008
BERKELEY, CA (UroToday.com) - Daniel Culkin, MD, Chair of Urology and lead clinical researcher teamed with Robert Hurst, PhD to investigate changes in the bladder urothelium that lead to the loss of impermeability.
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Beyond the Abstract - A Phase II Clinical Trial of Sorafenib in Androgen-Independent Prostate Cancer
Tuesday, 29 January 2008
BERKELEY, CA (UroToday.com) - Tumor angiogenesis have shown to be correlated with metastasis in invasive prostate carcinoma1.
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Beyond the Abstract - Detection of Prostate-Specific Antigen Coupled to Immunoglobulin M in Prostate Cancer Patients
Tuesday, 29 January 2008
BERKELEY, CA (UroToday.com) - Xeptagen findings published in the latest issue of Cancer Detection and Prevention may open a new gateway for the management of prostate cancer patients.
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Beyond the Abstract - Urethral Diverticulum after Endoscopic Urethrotomy
Tuesday, 29 January 2008
BERKELEY, CA (UroToday.com) - Diverticula of the male penile urethra are rare.
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Beyond the Abstract - The Effect of Age on Outcomes of Sling Surgery for Urinary Incontinence
Tuesday, 22 January 2008
BERKELEY, CA (UroToday.com) - This study demonstrates the need for caution when performing slings on older women with stress incontinence.
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Beyond the Abstract - Integrative Genomics Analysis Reveals Silencing of Beta-Adrenergic Signaling by Polycomb in Prostate Cancer
Tuesday, 22 January 2008
BERKELEY, CA (UroToday.com) - Prior analyses identified overexpression of the transcriptional repressor EZH2 as a significant predictor of poor outcome in organ-confined prostate cancer.
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Beyond the Abstract - Primary Testicular Lymphoma
Tuesday, 22 January 2008
BERKELEY, CA (UroToday.com) - Most patients with primary testicular lymphoma (PTL) present with limited disease and low or low-intermediate risk according to the International Prognostic Index.
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Beyond the Abstract - Is it Necessary to Cure Prostate Cancer When it is Possible? (Understanding the Role of Prostate Inflammation Resolution to Prostate Cancer Evolution)
Tuesday, 22 January 2008
BERKELEY, CA (UroToday.com) - Treating Prostate Cancer as a Chronic Disease is becoming increasingly popular among physicians who recognize that up to a third of all prostate cancer treatments are unnecessary.
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Beyond the Abstract - Testicular Microlithiasis as a Familial Risk Factor for Testicular Germ Cell Tumour
Tuesday, 22 January 2008
BERKELEY, CA (UroToday.com) - Our study, recently reported in the BJC, demonstrates for the first time that testicular microlithiasis (TM) is significantly more frequent in unaffected male relatives of testicular germ cell tumour (TGCT) cases than in healthy male controls.
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Beyond the Abstract - Pathological Evidence of Necrosis in Recurrent Renal Mass Following Treatment with Sunitinib
Tuesday, 22 January 2008
BERKELEY, CA (UroToday.com) - Sunitinib is a highly potent, selective inhibitor of certain protein tyrosine kinases, including VEGF-R types 1 to 3, PDGF-R- , and PDGF-R-ß.
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Beyond the Abstract - Prostate Biopsy Patterns in the CaPSURE Database: Evolution with Time and Impact on Outcome after Prostatectomy
Tuesday, 22 January 2008
BERKELEY, CA (UroToday.com) - The optimal method of timely and appropriate diagnosis of prostate cancer remains a matter of considerable debate.
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Beyond the Abstract - p53 Gene and Protein Status: The Role of p53 Alterations in Predicting Outcome in Patients with Bladder Cancer
Tuesday, 15 January 2008
BERKELEY, CA (UroToday.com) - The function of the normal product of the TP53 gene, the p53 protein, forms the crucial basis of normal cell biology; conversely, the dysfunction of its mutant protein product underlies altered cellular response in cancer.
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Beyond the Abstract - Sexual Function Reported by Japanese and American Men
Tuesday, 15 January 2008
BERKELEY, CA (UroToday.com) - We conducted a cross-cultural comparison of sexual function and bother in men with localized prostate cancer in the U.S. and Japan.
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Beyond the Abstract - Cholesterol-Lowering Drugs and Prostate Cancer Risk: A Population-Based Case-Control Study
Tuesday, 15 January 2008
BERKELEY, CA (UroToday.com) - This is a large case-control study estimating prostate cancer incidence among users of statins and other cholesterol-lowering drugs in a study population of 24,723 case-control pairs.
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Beyond the Abstract - Sequential Bilateral Minimum Incision Endoscopic Radical Nephrectomy in Dialysis Patients with Bilateral Renal Cell Carcinomas
Tuesday, 15 January 2008
BERKELEY, CA (UroToday.com) - Renal cell carcinoma (RCC) occurs in dialysis patients more frequent than the general non-dialyzed population.
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Beyond the Abstract - The Value of Combined Use of Survivin, Cytokeratin 20 and Mucin 7 mRNA for Bladder Cancer Detection in Voided Urine
Tuesday, 15 January 2008
BERKELEY, CA (UroToday.com) - This study analyzed the clinical value of combined use of survivin, cytokeratin (CK) 20, and mucin (MUC) 7 mRNA in the detection of bladder cancer patients in China.
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Beyond the Abstract - Maternal Smoking during Pregnancy Specifically Reduces Human Fetal Desert Hedgehog Gene Expression during Testis Development
Tuesday, 15 January 2008
BERKELEY, CA (UroToday.com) - In this article, published in the Journal of Clinical Endocrinology and Metabolism, Fowler and colleagues report that continued cigarette smoking by women with normally progressing pregnancies nearly halves Desert hedgehog (DHH) gene expression in the testes of second trimester fetuses.
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Beyond the Abstract - Sorafenib and Surgical Complications: A Case Report of Adverse Reaction to Sorafenib during Treatment for Renal Cell Carcinoma
Tuesday, 08 January 2008
BERKELEY, CA (UroToday.com) - In order to validate our observation that Sorafenib was the cause of the gross changes seen in the ileostomy, full thickness biopsies of the ileostomy were taken shortly after Sorafenib was discontinued.
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Beyond the Abstract - Urologist Practice Patterns in the Management of Peyronie's Disease: A Nationwide Survey
Tuesday, 08 January 2008
BERKELEY, CA (UroToday.com) - There is a lack of consensus on the optimal timing and management of Peyronie’s disease (PD).
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Beyond the Abstract - Development of De Novo Urge Incontinence in Women Post Sling: The Role of Preoperative Urodynamics in Assessing the Risk
Tuesday, 08 January 2008
BERKELEY, CA (UroToday.com) - Patients who develop de novo postoperative urge incontinence, report extremely low satisfaction after the surgery 1.
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Beyond the Abstract - Clusterin Isoforms Differentially Affect Growth and Motility of Prostate Cells: Possible Implications in Prostate Tumorigenesis
Tuesday, 08 January 2008
BERKELEY, CA (UroToday.com) - Despite the considerable attention that the Clusterin (CLU) gene has received from many research laboratories, its possible biological role is still debated.
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Beyond the Abstract - Long-Term Results of Reconstructive Surgery in Patients with Bladder Pain Syndrome/Interstitial Cystitis: Subtyping is Imperative
Tuesday, 08 January 2008
BERKELEY, CA (UroToday.com) - Our report includes 47 patients, evaluated retrospectively, fulfilling the NIH/NIDDK criteria and assigned to subtype: classic versus non-ulcer BPS/IC.
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Beyond the Abstract - Bladder-Sparing, Combined-Modality Approach for Muscle-Invasive Bladder Cancer : A Multi-Institutional, Long-Term Experience
Tuesday, 08 January 2008
BERKELEY, CA (UroToday.com) -The standard of care for localized muscle-invasive bladder cancer is radical cystectomy.
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Beyond the Abstract - Cathepsin B is Involved in the Apoptosis Intrinsic Pathway Induced by Bacillus Calmette-Guérin in Transitional Cancer Cell Lines
Friday, 21 December 2007
BERKELEY, CA (UroToday.com) - This is a basic research work, where we analyzed the direct effect of BCG on transitional cancer cells (TCC) murine (MB49) and human (T24) cells lines.
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Beyond the Abstract - Significance of Whole-Pelvic Radiotherapy for High-Risk Prostate Cancer Patients after Radical Prostatectomy
Friday, 21 December 2007
BERKELEY, CA (UroToday.com) - To conduct the combination therapy of radiation and hormonal therapy for high-risk prostate cancer patients, the field, dose and fractionation of irradiation and the timing and method of hormonal therapy are the issues of controversy.
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Beyond the Abstract - Midkine Promoter-Based Conditionally Replicative Adenovirus for Targeting MIDKINE-Expressing Human Bladder Cancer Model
Thursday, 13 December 2007
BERKELEY, CA (UroToday.com) - Conditionally replicative adenovirus (CRAD) is now widely used and has two major advantages for cancer gene therapy. The virus kills tumor cells selectively because tumor specific promoter controls the expression of E1a gene.
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Beyond the Abstract - Non-Steroidal Anti-Inflammatory Drugs in the Treatment of Genitourinary Malignancies: Focus on Clinical Data
Wednesday, 12 December 2007
BERKELEY, CA (UroToday.com) - Non-steroidal anti-inflammatory drugs (NSAIDs) have been available for many years and exert their anti-inflammatory effects primarily through inhibition of the cyclooxygenase (COX) enzymes.
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Beyond the Abstract 
