BERKELEY, CA (UroToday.com) - Various comorbidities are expected with PD, such as diabetes, hypertension, dyslipidemia, smoking, and coronary artery disease. A small study on 40 PD patients evaluated a number of demographic variables and analyzed the prevalence of comorbidities.⁵ This retrospective analysis reported diabetes and hypertension to be highly prevalent in men with PD.

Another clinical study compared the severity of penile deformity and penile blood flow parameters in PD men with diabetes only (n = 59, Group 1) and PD patients without any risk factors (n = 109, Group 2).⁶ All patients underwent penile duplex Doppler evaluation and were categorized into specific vascular groups using published criteria. Group 1 patients were older and their mean degree of penile curvatures was significantly higher than in Group 2 (45° vs. 30°). The more severe category of curvature (> 60°) was more frequently observed in Group 1 (27% vs. 5%) and, similarly, the rate of ED was more common in this group (81% vs. 47%). Group 1 exhibited lower peak systolic cavernosal arterial flow values and documents significantly higher rates of arterial insufficiency and mixed vascular disease. Pain with erection was, however, significantly higher in Group 2 (39% vs. 25%) and the non-vascular etiology was 2-fold more frequent in this group. This analysis suggests that diabetes increases the severity of PD and is associated with a significantly worse vascular status.

References:

• Davila HH, Garcia JE, Broderick G, Carrion RE. Demographic characteristics and the prevalence of comorbid conditions in patients with Peyronie's disease. J Sex Med 2005; 2 (Suppl 1):22 (Abstract #28).
• Kendirci M, Trost L, Sikka SC, Hellstrom WJG. Diabetes mellitus is a risk factor for increase severity of Peyronie's disease: a comparative clinical study. J Sex Med 2005; 3 (Suppl 1):36-7 (Abstract #72).

Addtional References

Summary of SMSNA Meeting, New York, New York, November 17 - 20, 2005
Author: Wayne J. G. Hellstrom, M.D., F.A.C.S.
Reviewed and Edited: GA Broderick

Written by Gregory A. Broderick, MD, a Contributing Editor with UroToday.

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