Abstract 692

He reviewed 864 men (mean age 52 years) participating in 2 lipid treatment studies and observed that aging men with obesity and METS (including diabetes) have a clinically significant decrease in total T levels. The median T for obese aging men with METS was 150 ng/dl less than lean aging men who do not have METS. Further almost 70% of obese aging males with METS have serum T levels less than 400 ng/dl. Dr. Kaplan concluded that ED in diabetic obese men probably involved a hypoandrogenic component.

Editor's Note: Urologist assessing and treating ED patients need to become familiar with metabolic syndrome (central obesity, hypertension, hyperlipidemia, diabetes); these patients are not only at risk for erectile dysfunction but have significantly higher risk of symptomatic coronary heart disease. Patients presenting to our practices with metabolic syndrome should be referred to internists, endocrinologists or diabetologists. There is the very real probability that these men will suffer symptomatic coronary artery disease and the presentation with ED may be a life saver if it leads to a thorough cardiovascular evaluation and subsequent risk reduction through exercise, diet and medical management. What remains to be determined is the role of testosterone in pathogenesis of metabolic syndrome and its potential efficacy in treatment.

Link: Abstract 692

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