Presented Wednesday, 05 September 2007 at the 29th Congress of the Societe International d'Urologie - SIU 2007 - Optimizing Clinical Outcomes in Prostate and Renal Cell Carcinomas - The Second Annual Symposium on Advanced GU Malignancy - Palais des Congres de Paris, France

Introduction: To evaluate health-related quality of life (HRQOL) in Japanese men with localized prostate cancer who underwent ¹²⁵I brachytherapy (BT), external beam radiation therapy after brachytherapy (EBRT+BT) or retropubic radical prostatectomy (RP).

Methods: From September 2003 to June 2005, 346 patients with localized prostate cancer were treated either with BT (n=150), EBRT+BT (n=109) or RP (n=87) at our institute. These patients were characterized with the International Prostate Symptom Score (IPSS), the RAND 36-Item Short Form (SF 36), the UCLA Prostate Cancer Index and the Expanded Prostate Cancer Index Composite (EPIC) questionnaire to clarify their HRQOL before and 1,6 and 12 months after the treatment.

Results: IPSS of all three groups significantly elevated after the treatment, however all returned to the baseline in 12 months. In RP group, physical functioning, general health and mental health index were significantly worse than those of the other treatments. RP had significantly worse postoperative urinary function than that of the other treatments, however returned to the baseline in 12 months. EBRT+BT had significantly worse postoperative bowel function and bother than that of the other treatments, which might be caused by EBRT.

Conclusion: RP may have an incidence to worsen HRQOL by voiding problem and EBRT may effect to worsen HRQOL by bowel problem. BT may cause minimum change in general HRQOL and seems to be superior to the other treatments from the point of QOL.

Authors: Kosugi M, Hanawa Y, Takeda T, Kono Y, Nagata H, Momma T, Ohashi T, Toya K, Yorozu A, Saito S

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