Ismail M., Ahmed S., Davies J.

Presented on March, 23 2007

INTRODUCTION & OBJECTIVES: In this study we report our experience in salvage cryotherapy for recurrent prostate cancer after radiation failure, evaluating the biochemical outcome, complications and management  and quality of life.

MATERIAL & METHODS: Between May 2000 and November 2005,100 patients underwent salvage cryoablation of the prostate. The mean follow-up was 27.5 months (range 6-73 months). The mean age was 67 years (range 54-78 years).All patients had biopsy proven recurrent prostate cancer. Two cryotherapy systems were used, Cryocare n=45 and Seednet n=55.Biochemical recurrence free survival was defined as PSA level <0.5 ng/ml. Patients were stratified into 3 risk groups according to the following factors: PSA level, Gleason score and clinical stage.

RESULTS: There were no operative or cancer related mortalities. Sixty one patients received hormonal therapy prior to their cryosurgery. The 5 years actuarial biochemical recurrence free survival was 73% for the low risk group, 45% for the intermediate risk group and 11% for the high risk group. Six patients had redo cryosurgery. Complications included incontinence (13%). Erectile dysfunction (85.5%), lower urinary tract symptoms (16%), prolonged perineal pain (4%), urinary retention 2% and rectovesical fistula 1%.

CONCLUSIONS: Salvage cryotherapy of the prostate is safe and effective treatment and offers additional hope of cure for patients with recurrent prostate cancer following radiotherapy.

UroToday.com Full Conference Coverage

Please log-in or register in order to submit comments.

Powered by AkoComment!