November 2009
The second-line management of idiopathic overactive bladder: What is the place of sacral neuromodulation and botulinum toxin-A in contemporary practice?
This review provides guidelines for specialized second-line management of OAB after failure with one or more antimuscarinic agents.
Environmental factors involved in carcinogenesis of urothelial cell carcinomas of the upper urinary tract
This review discusses the environmental factors, including tobacco use and occupational exposure, involved in upper urinary tract (UUT) carcinoma.
Key targets of hormonal treatment of prostate cancer. Part 2: The androgen receptor and 5α-reductase
The objective of this review is to provide an understanding of the pharmacological properties and the potential clinical benefits of 5AR inhibition in prostate cancer treatment.
Robotic-assisted radical prostatectomy: A review of current outcomes
This review provides an examination of the perioperative, oncological and functional outcomes of the largest RALP series recently published.
October 2009
Lingual mucosal grafts for anterior urethroplasty: A review
This article provides a critical review of recent reports of lingual mucosal grafts (LMGs) for substitution urethroplasty and examines the efficacy and complications of this approach.
Interest of methylated genes as biomarkers in urothelial cell carcinomas of the urinary tract
This review examines DNA methylation, an important epigenetic mechanism of gene regulation that plays essential roles in urothelial cell tumour initiation and progression.
September 2009
Secondary neoplasms of the urinary system and male genital organs
This review provides a discussion of those secondary tumours involving the urinary system and male genital organs that can pose differential diagnostic difficulties with primary lesions, and highlights morphological and ancillary features that could be helpful in reaching a proper assignment of primary origin.
The role of lymphangiogenesis in lymphatic tumour spread of urological cancers
This article summarizes preliminary evidence on the role of lymphangiogenesis during the formation of lymphatic metastasis in the most common urological cancers.
August 2009
Locally advanced prostate cancer: the role of surgical management
This review provides an examination of the role of radical prostatectomy for managing locally advanced prostate cancer.
Civiale, stones and statistics: the dawn of evidence-based medicine
This review looks at Jean Civiale, a French surgeon and urologist whose statistical research on bladder stones conducted in the early 19th century provided historical roots for evidence-based medicine.
Key targets of hormonal treatment of prostate cancer. Part 1: The androgen receptor and steroidogenic pathways
The objective of this review is to provide an understanding of the mechanisms that prostate cancer cells use to bypass androgen-deprived conditions.
July 2009
Should All Patients Receive Single Chemotherapeutic Agent Instillation after Bladder Tumour Resection?
This review aims to critically evaluate the role of a single intravesical instillation of chemotherapy in patients undergoing TURBT and to answer the question of whether all patients should receive single chemotherapeutic agent instillation after TURBT.
Optimal Management of Metastatic Renal Cell Carcinoma: An Algorithm for Treatment
This review provides a discussion of the available clinical evidence on targeted therapies and considers factors affecting treatment decisions in patients with metastatic renal cell carcinoma.
June 2009
Magnetic Resonance Spectroscopic Imaging: Current Status in the Management of Prostate Cancer
This article reviews the literature, technique and basics of MRSI and its current status in its application to the management of prostate cancer.
Neuroendocrine Tumours of the Urinary System and Male Genital Organs: Clinical Significance
The aim of this review is to discuss the clinical features, origins, morphological and immunophenotypic profiles, and prognosis of neuroendocrine tumours of the urinary system and male genital organs.
May 2009
Targeted Therapies in Metastatic Renal Cancer in 2009
This review assesses published reports on four targeted therapies (bevacizumab, sunitinib, sorafenib and temsirolimus) for the treatment of metastatic clear cell renal cell carcinoma.
On the Origins of the Sensory Output from the Bladder: The Concept of Afferent Noise
This review examines the diversity of the bladder afferent system and explores the underlying complexity between afferent and sensory information.
Laser Treatment of Benign Prostatic Hyperplasia in Patients on Oral Anticoagulant Therapy: A Review
This review assesses the therapeutic efficacy and safety of laser prostatectomy (LP) for treating benign prostatic hyperplasia (BPH) in patients on anticoagulants.
April 2009
Laparo-Endoscopic Single-Site Surgery: Preliminary Advances in Renal Surgery
This review examines the preliminary advances in laparo-endoscopic single-site surgery (LESS) as applied to renal surgery and analyzes current publications based on animal models and human patients.
Prostate Cancer: A Serious Disease Suitable for Prevention
The objective of this review is to examine the significant burden imposed by prostate cancer, the characteristics of prostate cancer that make it suitable for a risk-reduction approach, and potential drug candidates for reducing the risk of prostate cancer.
March 2009
The Medical Management of Metastatic Renal Cell Carcinoma: Integrating New Guidelines and Recommendations
This review examines a landscape, radically changed by the introduction of five agents tested in phase III clinical trials, that have been designed to target tumour-related angiogenesis and signal transduction in renal cell carcinoma.
Prostate-Specific Antigen Kinetics in Localized and Advanced Prostate Cancer
In this review, the authors examine publications on the added value of PSA kinetics compared with single PSA measurements in the early detection of prostate cancer and in predicting the outcome of patients with localized and advanced disease.
Therapeutic Options in the Management of Intermediate-Risk Nonmuscle-Invasive Bladder Cancer
This article reviews current treatment options, recent advances, and future developments in the treatment of patients with intermediate-risk non-muscle-invasive bladder cancer.
The Role of Magnetic Resonance Imaging in Targeting Prostate Cancer in Patients with Previous Negative Biopsies and Elevated Prostate-Specific Antigen Levels
This article offers a summary of current data on the efficacy of MRI for targeting cancer, compared with biopsies, in patients with previous negative prostate biopsies and persistently elevated prostate-specific antigen (PSA) levels.
February 2009
Nephroptosis: Seriously Misunderstood?
This review examines nephroptosis, which has been one of the most controversial and often debated urological diagnoses for more than a century.
Prostate Cancer Diagnosis in the New Millennium: Strengths and Weaknesses of Prostate-Specific Antigen and the Discovery and Clinical Evaluation of Prostate Cancer Gene 3 (PCA3)
This review examines the current diagnostic dilemmas, the weaknesses of traditional testing, and the potential of PCA3 to complement existing diagnostic methods.
Src as a Therapeutic Target in Men with Prostate Cancer and Bone Metastases
This review explores Src inhibition as a strategy for managing bone metastasis in prostate cancer, with a particular focus on targeting the critical osteoclastic response.
January 2009
Pre-Surgical Targeted Molecular Therapy in Renal Cell Carcinoma
This review provides an examination of pre-surgical systemic therapy with targeted molecular agents, an attractive option as an approach to the treatment of patients with renal cell carcinoma.
A Critical Analysis of the Role of Gut Oxalobacter Formigenes in Oxalate Stone Disease
This review critically evaluates published studies about the gut-dwelling obligate anaerobe Oxalobacter formigenes (OF) which has attracted attention for its oxalate-degrading property.
The Role of Systemic Cytotoxic Therapy for Prostate Cancer
This review examines the use of chemotherapy in the treatment and management of hormone refractory prostate cancer.
Two Centuries of Cystoscopy: The Development of Imaging, Instrumentation and Synergistic Technologies
This review describes the pivotal events in the evolution and development of modern cystoscopy and endoscopy.
|
